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Tclin
FGF23
Fibroblast growth factor 23

Protein Summary
Description
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237837
  • ENSP00000237837
  • ENSG00000118972

Symbol
  • HYPF
  • ADHR
  • FGFN
  • HYPF
  • HFTC2
  • HPDR2
  • PHPTC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.99
biological process
0.96
phenotype
0.72
cell line
0.65
pathway
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2656.78   (req: < 5)
Gene RIFs: 426   (req: <= 3)
Antibodies: 462   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2656.78   (req: >= 5)
Gene RIFs: 426   (req: > 3)
Antibodies: 462   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
burosumab
no chemical structure image available
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (157)
Activated point mutants of FGFR2 (R-HSA-2033519)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 78
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated point mutants of FGFR2
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Gene Ontology Terms (33)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (279)
1 – 10 of 279
KL
Tbio
Family: Enzyme
Novelty: 0.00096954
Score: 0.999
Data Source: Reactome,STRINGDB
FGFR1
Tclin
Family: Kinase
Novelty: 0.00055714
Score: 0.996
Data Source: Reactome,STRINGDB
GALNT3
Tbio
Family: Enzyme
Novelty: 0.01140808
Score: 0.991
Data Source: Reactome,STRINGDB
FGFR4
Tclin
Family: Kinase
Novelty: 0.00258329
Score: 0.985
Data Source: STRINGDB
FGFR3
Tclin
Family: Kinase
Novelty: 0.00071612
Score: 0.985
Data Source: STRINGDB
FGFR2
Tclin
Family: Kinase
Novelty: 0.00066613
Score: 0.984
Data Source: STRINGDB
FAM20C
Tbio
Family: Enzyme
Novelty: 0.00318966
Score: 0.983
Data Source: STRINGDB
DMP1
Tbio
Novelty: 0.03114505
Score: 0.982
Data Source: STRINGDB
MEPE
Tbio
Novelty: 0.00825085
Score: 0.978
Data Source: STRINGDB
PTH
Tbio
Novelty: 0.00003263
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  2656.78

PubMed score by year
PubTator Score  1587.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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