You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

Protein Summary
Description
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. A ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237530
  • ENSP00000237530
  • ENSG00000118705
  • ENST00000373622
  • ENSP00000362724

Symbol
  • SWP1
  • RPNII
  • RIBIIR
  • RPN-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
interacting protein
0.99
disease perturbation
0.96
histone modification site profile
0.88
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.98   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.98   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
10.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
10.4
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SRP-dependent cotranslational protein targeting to membrane
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Metabolism of proteins
Post-translational protein modification
SRP-dependent cotranslational protein targeting to membrane
Translation
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (250)
1 – 10 of 250
EIF2AK3
Tchem
Family: Kinase
Novelty: 0.00044559
p_int: 0.999992807
p_ni: 0.000007192
Data Source: BioPlex
LIN54
Tbio
Novelty: 0.06173892
p_int: 0.999986811
p_ni: 0.000013189
Score: 0.561
Data Source: BioPlex,STRINGDB
FAM241A
Tdark
Novelty: 1.04041354
p_int: 0.999979044
p_ni: 0.000020956
Data Source: BioPlex
TUSC3
Tbio
Novelty: 0.01388722
p_int: 0.999921307
p_ni: 0.000078693
Score: 0.997
Data Source: BioPlex,STRINGDB
DSG4
Tbio
Novelty: 0.01599371
p_int: 0.999698165
p_ni: 0.000301834
Data Source: BioPlex
TMEM258
Tdark
Novelty: 0.22121107
p_int: 0.999516763
p_ni: 6.87e-7
p_wrong: 0.00048255
Score: 0.825
Data Source: BioPlex,STRINGDB
VSIG8
Tdark
Novelty: 1.16023405
p_int: 0.999444602
p_ni: 0.000555398
Data Source: BioPlex
DDOST
Tchem
Family: Enzyme
Novelty: 0.01797594
p_int: 0.99884941
p_ni: 0.001150589
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
HEPHL1
Tbio
Novelty: 0.44678065
p_int: 0.996294117
p_ni: 0.003705883
Score: 0.16
Data Source: BioPlex,STRINGDB
LYG2
Tbio
Family: Enzyme
Novelty: 0.12091256
p_int: 0.995011346
p_ni: 0.004988654
Data Source: BioPlex
Publication Statistics
PubMed Score  59.98

PubMed score by year
PubTator Score  41.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer