Tchem MMP8 Neutrophil collagenase

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Neutrophil Collagenase

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Neutrophil Collagenase

Protein Summary

Description

Can degrade fibrillar type I, II, and III collagens. This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• P22894
• Q45F99

Gene Name

• MMP8

Ensembl ID

• ENST00000236826
• ENSP00000236826
• ENSG00000118113

Symbol

• CLG1
• HNC
• CLG1
• MMP-8
• PMNL-CL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
biological term	0.86
cell type or tissue	0.76
drug	0.72
disease	0.68

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1003.4   (req: < 5)

Gene RIFs: 151   (req: <= 3)

Antibodies: 598   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1003.4   (req: >= 5)

Gene RIFs: 151   (req: > 3)

Antibodies: 598   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 891

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (891)

Explore Active Ligands

1 – 10 of 891

CHEMBL514138

MMP8Tchem Enzyme

IC50: 8.7

CHEMBL19611

MMP8Tchem Enzyme

Ki: 9.74

CHEMBL279785

MMP8Tchem Enzyme

IC50: 9.33

CHEMBL440498

MMP8Tchem Enzyme

IC50: 10.01

CHEMBL75094

MMP8Tchem Enzyme

IC50: 9.27

CHEMBL115653

MMP8Tchem Enzyme

Ki: 8.4

CHEMBL187092

MMP8Tchem Enzyme

IC50: 9

CHEMBL3675563

MMP8Tchem Enzyme

Ki: 6.88

CHEMBL11306

MMP8Tchem Enzyme

Ki: 8.7

CHEMBL148169

MMP8Tchem Enzyme

Ki: 6.59

Protein Data Bank (25)

1 – 5 of 25

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (21)

Reactome (7)

PathwayCommons (1)

WikiPathways (13)

Activation of Matrix Metalloproteinases (R-HSA-1592389)

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Items per page:

5

1 – 5 of 7

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of Matrix Metalloproteinases	33 targets	R-HSA-1592389
Reactome	Collagen degradation	40 targets	R-HSA-1442490
Reactome	Degradation of the extracellular matrix	111 targets	R-HSA-1474228
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Activation of Matrix Metalloproteinases	33 targets	R-HSA-1592389
Collagen degradation	40 targets	R-HSA-1442490
Degradation of the extracellular matrix	111 targets	R-HSA-1474228
Extracellular matrix organization	297 targets	R-HSA-1474244
Immune System	2246 targets	R-HSA-168256

Gene Ontology Terms (29)

Functions (4)

Components (5)

Processes (20)

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
serine-type endopeptidase activity	Inferred from Direct Assay (IDA)	UniProtKB
endopeptidase activity	Inferred from Mutant Phenotype (IMP)	ARUK-UCL
metalloendopeptidase activity	Traceable Author Statement (TAS)	Reactome
zinc ion binding	Traceable Author Statement (TAS)	UniProtKB

Protein-Protein Interactions (166)

Explore Interacting Targets

1 – 10 of 166

• See Interactions on String-DB

TIMP2

Tbio

Family: Enzyme

Novelty: 0.00074145

Score: 0.985

Data Source: STRINGDB

ELANE

Tclin

Family: Enzyme

Novelty: 0.00030106

Score: 0.967

Data Source: STRINGDB

MMP9

Tchem

Family: Enzyme

Novelty: 0.00010127

Score: 0.964

Data Source: STRINGDB

DEFA4

Tbio

Novelty: 0.09939219

Score: 0.959

Data Source: STRINGDB

TCN1

Tbio

Novelty: 0.00420205

Score: 0.955

Data Source: STRINGDB

PLG

Tclin

Family: Enzyme

Novelty: 0.00005824

Score: 0.954

Data Source: STRINGDB

ARG1

Tchem

Family: Enzyme

Novelty: 0.00066279

Score: 0.95

Data Source: STRINGDB

LTF

Tbio

Novelty: 0.00144682

Score: 0.949

Data Source: STRINGDB

LCN2

Tbio

Family: Enzyme

Novelty: 0.00038637

Score: 0.948

Data Source: STRINGDB

CXCL1

Tbio

Novelty: 0.00066136

Score: 0.941

Data Source: STRINGDB

Publication Statistics

PubMed Score  1003.40

PubMed score by year

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PubTator Score  766.68

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFF

1-70

GLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELW

70-140

SVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYN

140-210

LFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCD

210-280

PSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYW

280-350

ALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI

350-420

ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG

420-467

MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG

Find similar targets by:

Uniprot Keyword

3D-structure
Calcium
Collagen degradation
Complete proteome
Direct protein sequencing
Disulfide bond
Extracellular matrix
Glycoprotein
Hydrolase
Metal-binding