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Tchem
MMP8
Neutrophil collagenase

Protein Summary
Description
Can degrade fibrillar type I, II, and III collagens. This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236826
  • ENSP00000236826
  • ENSG00000118113

Symbol
  • CLG1
  • HNC
  • CLG1
  • MMP-8
  • PMNL-CL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological term
0.86
cell type or tissue
0.76
drug
0.72
disease
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1003.4   (req: < 5)
Gene RIFs: 151   (req: <= 3)
Antibodies: 598   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1003.4   (req: >= 5)
Gene RIFs: 151   (req: > 3)
Antibodies: 598   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 891
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (25)
1 – 5 of 25
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (21)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Collagen degradation
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Collagen degradation
Degradation of the extracellular matrix
Extracellular matrix organization
Immune System
Protein-Protein Interactions (166)
1 – 10 of 166
TIMP2
Tbio
Family: Enzyme
Novelty: 0.00074145
Score: 0.985
Data Source: STRINGDB
ELANE
Tclin
Family: Enzyme
Novelty: 0.00030106
Score: 0.967
Data Source: STRINGDB
MMP9
Tchem
Family: Enzyme
Novelty: 0.00010127
Score: 0.964
Data Source: STRINGDB
DEFA4
Tbio
Novelty: 0.09939219
Score: 0.959
Data Source: STRINGDB
TCN1
Tbio
Novelty: 0.00420205
Score: 0.955
Data Source: STRINGDB
PLG
Tclin
Family: Enzyme
Novelty: 0.00005824
Score: 0.954
Data Source: STRINGDB
ARG1
Tchem
Family: Enzyme
Novelty: 0.00066279
Score: 0.95
Data Source: STRINGDB
LTF
Tbio
Novelty: 0.00144682
Score: 0.949
Data Source: STRINGDB
LCN2
Tbio
Family: Enzyme
Novelty: 0.00038637
Score: 0.948
Data Source: STRINGDB
CXCL1
Tbio
Novelty: 0.00066136
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  1003.40

PubMed score by year
PubTator Score  766.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFF
1-70
GLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELW
70-140
SVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYN
140-210
LFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCD
210-280
PSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYW
280-350
ALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
350-420
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
420-467
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG