Protein Classes
Protein Summary
Can degrade fibrillar type I, II, and III collagens. This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1003.4 (req: < 5)
Gene RIFs: 151 (req: <= 3)
Antibodies: 598 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1003.4 (req: >= 5)
Gene RIFs: 151 (req: > 3)
Antibodies: 598 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 891
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (891)
1 – 10 of 891
Protein Data Bank (25)
1 – 5 of 25
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (21)
Reactome (7)
PathwayCommons (1)
WikiPathways (13)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 7
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of Matrix Metalloproteinases | ||||
Reactome | Collagen degradation | ||||
Reactome | Degradation of the extracellular matrix | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of Matrix Metalloproteinases | ||||
Collagen degradation | ||||
Degradation of the extracellular matrix | ||||
Extracellular matrix organization | ||||
Immune System | ||||
Gene Ontology Terms (29)
Functions (4)
Components (5)
Processes (20)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | ARUK-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Protein-Protein Interactions (166)
1 – 10 of 166
TIMP2
Family: Enzyme
Novelty: 0.00074145
Score: 0.985
Data Source: STRINGDB
ELANE
Family: Enzyme
Novelty: 0.00030106
Score: 0.967
Data Source: STRINGDB
MMP9
Family: Enzyme
Novelty: 0.00010127
Score: 0.964
Data Source: STRINGDB
DEFA4
Novelty: 0.09939219
Score: 0.959
Data Source: STRINGDB
TCN1
Novelty: 0.00420205
Score: 0.955
Data Source: STRINGDB
PLG
Family: Enzyme
Novelty: 0.00005824
Score: 0.954
Data Source: STRINGDB
ARG1
Family: Enzyme
Novelty: 0.00066279
Score: 0.95
Data Source: STRINGDB
LTF
Novelty: 0.00144682
Score: 0.949
Data Source: STRINGDB
LCN2
Family: Enzyme
Novelty: 0.00038637
Score: 0.948
Data Source: STRINGDB
CXCL1
Novelty: 0.00066136
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score 1003.40
PubMed score by year
PubTator Score 766.68
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFF
1-70
GLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELW
70-140
SVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYN
140-210
LFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCD
210-280
PSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYW
280-350
ALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
350-420
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
420-467
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
Find similar targets by: