MMP8
Neutrophil collagenase
Protein Summary
Can degrade fibrillar type I, II, and III collagens. This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
- ENST00000236826
- ENSP00000236826
- ENSG00000118113
- CLG1
- HNC
- CLG1
- MMP-8
- PMNL-CL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
biological term | 0.86 | ||
cell type or tissue | 0.76 | ||
drug | 0.72 | ||
disease | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1141.16 (req: < 5)
Gene RIFs: 197 (req: <= 3)
Antibodies: 598 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1141.16 (req: >= 5)
Gene RIFs: 197 (req: > 3)
Antibodies: 598 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 935
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0