You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
P3H1
Prolyl 3-hydroxylase 1

Protein Summary
Description
Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts. This gene encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated with osteogenesis imperfecta type VIII. Three alternatively spliced transcript variants encoding different isoforms have been described. Other variants may exist, but their biological validity has not been determined. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236040
  • ENSP00000236040
  • ENSG00000117385
  • ENST00000296388
  • ENSP00000296388
  • ENST00000397054
  • ENSP00000380245

Symbol
  • GROS1
  • LEPRE1
  • OI8
  • GROS1
  • LEPRE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
transcription factor perturbation
0.84
histone modification site profile
0.81
cellular component
0.8
interacting protein
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.97   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.97   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen formation
Extracellular matrix organization
Gene Ontology Terms (20)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (106)
1 – 10 of 106
RENBP
Tbio
Family: Enzyme
Novelty: 0.02220005
p_int: 0.999921012
p_ni: 1.2e-7
p_wrong: 0.000078868
Score: 0.403
Data Source: BioPlex,STRINGDB
KRBA1
Tdark
Novelty: 2.59384945
p_int: 0.999419425
p_ni: 0.000580575
Data Source: BioPlex
TIGD5
Tdark
Novelty: 1.93340494
p_int: 0.997475227
p_ni: 0.002524773
Data Source: BioPlex
UQCC1
Tbio
Family: Enzyme
Novelty: 0.03937066
p_int: 0.991771672
p_ni: 0.008228328
Score: 0.244
Data Source: BioPlex,STRINGDB
CRTAP
Tbio
Novelty: 0.02380647
p_int: 0.989485329
p_ni: 0.010514671
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
HRG
Tbio
Novelty: 0.0027048
p_int: 0.987332824
p_ni: 0.012667176
Data Source: BioPlex
INAVA
Tbio
Novelty: 0.19311978
p_int: 0.975893546
p_ni: 0.024106454
Score: 0.185
Data Source: BioPlex,STRINGDB
HOOK2
Tbio
Novelty: 0.03559628
p_int: 0.97587506
p_ni: 0.02412494
Score: 0.183
Data Source: BioPlex,STRINGDB
VPS37D
Tdark
Novelty: 1.44882563
p_int: 0.974563925
p_ni: 0.025436075
Score: 0.6
Data Source: BioPlex,STRINGDB
EDA
Tbio
Novelty: 0.00352464
p_int: 0.970072268
p_ni: 0.029927732
Data Source: BioPlex
Publication Statistics
PubMed Score  50.97

PubMed score by year
PubTator Score  29.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: