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Tclin
OPRD1
Delta-type opioid receptor

Protein Summary
Description
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234961
  • ENSP00000234961
  • ENSG00000116329

Symbol
  • OPRD
  • DOP
  • DOR
  • DOR1
  • OPRD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.98
ligand (chemical)
0.98
biological process
0.89
gene perturbation
0.76
chemical
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.47   (req: < 5)
Gene RIFs: 77   (req: <= 3)
Antibodies: 380   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.47   (req: >= 5)
Gene RIFs: 77   (req: > 3)
Antibodies: 380   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1746
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 15
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
59
mean platelet volume
1
1
1
56.7
self reported educational attainment
1
1
1
54.7
platelet count
2
2
2
51.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
59
mean platelet volume
1
56.7
self reported educational attainment
1
54.7
platelet count
2
51.2
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (21)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (37)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (349)
1 – 10 of 349
PDYN
Tbio
Novelty: 0.00039564
Score: 0.992
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.986
Data Source: STRINGDB
CNR1
Tclin
Family: GPCR
Novelty: 0.00060063
Score: 0.983
Data Source: STRINGDB
PNOC
Tbio
Novelty: 0.00132014
Score: 0.977
Data Source: STRINGDB
PENK
Tbio
Novelty: 0.00074167
Score: 0.976
Data Source: STRINGDB
CNR2
Tchem
Family: GPCR
Novelty: 0.00215391
Score: 0.965
Data Source: STRINGDB
GABBR1
Tclin
Family: GPCR
Novelty: 0.00086493
Score: 0.956
Data Source: STRINGDB
NPY
Tbio
Novelty: 0.00012637
Score: 0.956
Data Source: STRINGDB
KNG1
Tchem
Novelty: 0.00007684
Score: 0.956
Data Source: STRINGDB
SST
Tbio
Novelty: 0.00005944
Score: 0.952
Data Source: STRINGDB
Publication Statistics
PubMed Score  118.47

PubMed score by year
PubTator Score  96.7

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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