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Tbio
CLCA1
Calcium-activated chloride channel regulator 1

Protein Summary
Description
May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234701
  • ENSP00000234701
  • ENSG00000016490
  • ENST00000394711
  • ENSP00000378200

Symbol
  • CACC1
  • CACC
  • GOB5
  • CACC1
  • CLCRG1
  • CaCC-1
  • hCLCA1
  • hCaCC-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
molecular function
0.88
cell type or tissue
0.8
cell line
0.72
cellular component
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.82   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.82   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (6)
Ion channel transport (R-HSA-983712)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Protein-Protein Interactions (77)
1 – 10 of 77
CLCA4
Tbio
Family: IC
Novelty: 0.05891943
Score: 0.92
Data Source: STRINGDB
CLCA2
Tbio
Family: IC
Novelty: 0.0306541
Score: 0.907
Data Source: STRINGDB
IL13
Tbio
Novelty: 0.00021435
Score: 0.794
Data Source: STRINGDB
SERPINB2
Tbio
Novelty: 0.00204345
Score: 0.748
Data Source: STRINGDB
SLC13A2
Tbio
Family: Transporter
Novelty: 0.01020451
Score: 0.748
Data Source: STRINGDB
POSTN
Tbio
Novelty: 0.00108629
Score: 0.741
Data Source: STRINGDB
MUC5AC
Tbio
Novelty: 0.00074159
Score: 0.74
Data Source: STRINGDB
SI
Tchem
Family: Enzyme
Novelty: 0.00048694
Score: 0.726
Data Source: STRINGDB
FKBP5
Tchem
Family: Enzyme
Novelty: 0.00214511
Score: 0.714
Data Source: STRINGDB
FKBP4
Tchem
Family: Enzyme
Novelty: 0.0023525
Score: 0.712
Data Source: STRINGDB
Publication Statistics
PubMed Score  97.82

PubMed score by year
PubTator Score  108.58

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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