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Tbio
MSH6
DNA mismatch repair protein Msh6

Protein Summary
Description
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234420
  • ENSP00000234420
  • ENSG00000116062
  • ENST00000538136
  • ENSP00000438580
  • ENST00000540021
  • ENSP00000446475
  • ENST00000614496
  • ENSP00000477844

Symbol
  • GTBP
  • GTBP
  • HSAP
  • p160
  • GTMBP
  • HNPCC5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
1
protein complex
1
hub protein
0.99
protein domain
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 962.96   (req: < 5)
Gene RIFs: 193   (req: <= 3)
Antibodies: 590   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 962.96   (req: >= 5)
Gene RIFs: 193   (req: > 3)
Antibodies: 590   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
93.4
age at menopause
1
1
1
44.3
risk-taking behaviour
1
1
1
18.4
heel bone mineral density
1
1
1
16.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
93.4
age at menopause
1
44.3
risk-taking behaviour
1
18.4
heel bone mineral density
1
16.4
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Defective Mismatch Repair Associated With MSH2
Reactome
Defective Mismatch Repair Associated With MSH6
Reactome
Disease
Reactome
Diseases of Mismatch Repair (MMR)
Name
Explore in Pharos
Explore in Source
DNA Repair
Defective Mismatch Repair Associated With MSH2
Defective Mismatch Repair Associated With MSH6
Disease
Diseases of Mismatch Repair (MMR)
Gene Ontology Terms (37)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (296)
1 – 10 of 296
GTF3C4
Tdark
Family: Epigenetic
Novelty: 0.28198123
p_int: 0.877975227
p_ni: 0.122024773
Data Source: BioPlex
MSH2
Tbio
Novelty: 0.00054283
Score: 0.999
Data Source: Reactome,STRINGDB
PMS2
Tbio
Family: Enzyme
Novelty: 0.00139084
Score: 0.999
Data Source: Reactome,STRINGDB
PCNA
Tchem
Novelty: 0.03909539
Score: 0.999
Data Source: Reactome,STRINGDB
MLH1
Tbio
Novelty: 0.00034212
Score: 0.999
Data Source: Reactome,STRINGDB
POLD1
Tclin
Family: Enzyme
Novelty: 0.00508209
Score: 0.996
Data Source: STRINGDB
EXO1
Tbio
Family: Enzyme
Novelty: 0.00130104
Score: 0.994
Data Source: Reactome,STRINGDB
MSH3
Tbio
Novelty: 0.0036266
Score: 0.992
Data Source: STRINGDB
XRCC6
Tbio
Novelty: 0.00127955
Score: 0.99
Data Source: STRINGDB
ATM
Tchem
Family: Kinase
Novelty: 0.00019169
Score: 0.989
Data Source: STRINGDB
Publication Statistics
PubMed Score  962.96

PubMed score by year
PubTator Score  790.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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