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Tclin
ODC1
Ornithine decarboxylase

Protein Summary
Description
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234111
  • ENSP00000234111
  • ENSG00000115758
  • ENST00000405333
  • ENSP00000385333

Symbol
  • ODC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
chemical
0.97
protein domain
0.97
transcription factor binding site profile
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2778.78   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 817   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2778.78   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 817   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
eflornithine
chemical structure image
Active Ligands (2)
1 – 2 of 2
CHEMBL2261742
chemical structure image
APA
chemical structure image
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of polyamines
Reactome
Regulation of ornithine decarboxylase (ODC)
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Metabolism of polyamines
Regulation of ornithine decarboxylase (ODC)
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (166)
1 – 10 of 166
OAZ3
Tbio
Family: Enzyme
Novelty: 0.02374168
p_int: 0.999999997
p_ni: 1e-9
p_wrong: 2e-9
Score: 0.984
Data Source: BioPlex,Reactome,STRINGDB
OAZ1
Tbio
Family: Enzyme
Novelty: 0.0224953
Score: 0.999
Data Source: Reactome,STRINGDB
SRM
Tchem
Family: Enzyme
Novelty: 0.01583759
Score: 0.996
Data Source: STRINGDB
OAZ2
Tbio
Family: Enzyme
Novelty: 0.1687351
Score: 0.994
Data Source: Reactome,STRINGDB
SAT1
Tbio
Family: Enzyme
Novelty: 0.0022456
Score: 0.987
Data Source: STRINGDB
OAT
Tchem
Family: Enzyme
Novelty: 0.00125611
Score: 0.987
Data Source: STRINGDB
ARG2
Tchem
Family: Enzyme
Novelty: 0.0006655
Score: 0.983
Data Source: STRINGDB
AGMAT
Tbio
Family: Enzyme
Novelty: 0.03970349
Score: 0.983
Data Source: STRINGDB
ARG1
Tchem
Family: Enzyme
Novelty: 0.00063728
Score: 0.975
Data Source: STRINGDB
AOC1
Tchem
Family: Enzyme
Novelty: 0.00146464
Score: 0.972
Data Source: STRINGDB
Publication Statistics
PubMed Score  2778.78

PubMed score by year
PubTator Score  1998.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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