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Tbio
HSPE1
10 kDa heat shock protein, mitochondrial

Protein Classes
Protein Summary
Description
Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:7912672, PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233893
  • ENSP00000233893
  • ENSG00000115541

Symbol
  • EPF
  • CPN10
  • GROES
  • HSP10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
disease perturbation
0.93
transcription factor binding site profile
0.9
molecular function
0.88
histone modification site profile
0.82


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1246.11   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 489   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1246.11   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 489   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family E (Hsp10) member 1
VGNC:10839
459853
Mouse
MGI:104680
15528
Rat
RGD:2844
25462
Horse
10 kDa heat shock protein, mitochondrial
100070523
Cow
heat shock protein family E (Hsp10) member 1
VGNC:49071
281833
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family E (Hsp10) member 1
Mouse
Rat
Horse
10 kDa heat shock protein, mitochondrial
Cow
heat shock protein family E (Hsp10) member 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P61604-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (296)
1 – 10 of 296
HSPD1
Tbio
Novelty: 0.00018924
Score: 0.999
Data Source: STRINGDB
HSPA9
Tbio
Novelty: 0.00235171
Score: 0.982
Data Source: STRINGDB
HSP90AA1
Tchem
Novelty: 0.00016774
Score: 0.971
Data Source: STRINGDB
GRPEL1
Tbio
Novelty: 0.00185346
Score: 0.961
Data Source: STRINGDB
CLPB
Tbio
Family: Enzyme
Novelty: 0.00209789
Score: 0.932
Data Source: STRINGDB
TXN
Tchem
Novelty: 0.00048949
Score: 0.93
Data Source: STRINGDB
HSPA4
Tbio
Novelty: 0.00009122
Score: 0.898
Data Source: STRINGDB
CYCS
Tchem
Novelty: 0.00014004
Score: 0.898
Data Source: STRINGDB
HSP90AB1
Tchem
Novelty: 0.00907961
Score: 0.893
Data Source: STRINGDB
TCP1
Tbio
Novelty: 0.00395241
Score: 0.862
Data Source: STRINGDB
Publication Statistics
PubMed Score  1246.11

PubMed score by year
PubTator Score  527.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer