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Tbio
NEU2
Sialidase-2

Protein Classes
Protein Summary
Description
Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides. This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233840
  • ENSP00000233840
  • ENSG00000115488

Symbol
  • SIAL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.73
gene perturbation
0.59
tissue
0.59
biological process
0.49
metabolite
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.9   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.9   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
19.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
19.1
Protein Data Bank (16)
1 – 5 of 16
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Protein-Protein Interactions (77)
1 – 10 of 77
PEX5
Tbio
Novelty: 0.00560901
p_int: 0.999999769
p_ni: 2.31e-7
Score: 0.248
Data Source: BioPlex,STRINGDB
FAM217B
Tdark
Novelty: 4.03122155
p_int: 0.999999546
p_ni: 4.54e-7
Score: 0.181
Data Source: BioPlex,STRINGDB
CWF19L2
Tdark
Novelty: 0.80210985
p_int: 0.999969316
p_ni: 0.000030684
Data Source: BioPlex
TFAP4
Tbio
Family: TF
Novelty: 0.03155887
p_int: 0.99992352
p_ni: 0.000076395
p_wrong: 8.4e-8
Score: 0.534
Data Source: BioPlex,STRINGDB
ALKBH3
Tchem
Family: Enzyme
Novelty: 0.02040675
p_int: 0.999847993
p_ni: 0.000151979
p_wrong: 2.7e-8
Score: 0.169
Data Source: BioPlex,STRINGDB
FBXL4
Tbio
Novelty: 0.04286856
p_int: 0.99721021
p_ni: 0.002789788
p_wrong: 2e-9
Data Source: BioPlex
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.995510499
p_ni: 0.004482724
p_wrong: 0.000006777
Data Source: BioPlex
RPN2
Tbio
Family: Enzyme
Novelty: 0.01796569
p_int: 0.991475353
p_ni: 0.008524645
p_wrong: 2e-9
Data Source: BioPlex
IL31RA
Tbio
Novelty: 0.00737445
p_int: 0.990770135
p_ni: 0.009229854
p_wrong: 1.1e-8
Data Source: BioPlex
KIAA1671
Tdark
Novelty: 1.1816849
p_int: 0.984413706
p_ni: 0.015586294
Score: 0.204
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  195.90

PubMed score by year
PubTator Score  50.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer