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Tclin
GGCX
Vitamin K-dependent gamma-carboxylase

Protein Summary
Description
Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. This gene encodes an integral membrane protein of the rough endoplasmic reticulum that carboxylates glutamate residues of vitamin K-dependent proteins to gamma carboxyl glutamate, a modification that is required for their activity. The vitamin K-dependent protein substrates have a propeptide that binds the enzyme, with carbon dioxide, dioxide, and reduced vitamin K acting as co-substrates. Vitamin K-dependent proteins affect a number of physiologic processes including blood coagulation, prevention of vascular calcification, and inflammation. Allelic variants of this gene have been associated with pseudoxanthoma elasticum-like disorder with associated multiple coagulation factor deficiency. Alternative splicing results in multiple transcript variants. [provided by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233838
  • ENSP00000233838
  • ENSG00000115486
  • ENST00000430215
  • ENSP00000408045

Symbol
  • GC
  • VKCFD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
kinase perturbation
0.88
microRNA
0.87
histone modification site profile
0.82
tissue sample
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.91   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.91   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
anisindione
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
69.3
prostate carcinoma
1
1
0
1.1
67.2
1
1
0
1.1
38.9
reticulocyte count
1
1
1
13.8
triglyceride measurement
1
1
1
10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
69.3
prostate carcinoma
0
1.1
67.2
0
1.1
38.9
reticulocyte count
1
13.8
triglyceride measurement
1
10
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gamma-glutamyl carboxylase
VGNC:269
459364
Macaque
gamma-glutamyl carboxylase
695628
Mouse
MGI:1927655
56316
Rat
RGD:68383
81716
Dog
gamma-glutamyl carboxylase
VGNC:41197
475769
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gamma-glutamyl carboxylase
Macaque
gamma-glutamyl carboxylase
Mouse
Rat
Dog
gamma-glutamyl carboxylase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P38435-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Gamma-carboxylation of protein precursors
Reactome
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Gamma-carboxylation of protein precursors
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (51)
1 – 10 of 51
TMCO3
Tdark
Novelty: 1.16719823
p_int: 0.823871266
p_ni: 0.176128734
Score: 0.197
Data Source: BioPlex,STRINGDB
VKORC1
Tclin
Family: Enzyme
Novelty: 0.00135838
Score: 0.991
Data Source: STRINGDB
F7
Tchem
Family: Enzyme
Novelty: 0.0002521
Score: 0.975
Data Source: Reactome,STRINGDB
BGLAP
Tbio
Novelty: 0.00009678
Score: 0.975
Data Source: Reactome,STRINGDB
F9
Tchem
Family: Enzyme
Novelty: 0.00032127
Score: 0.974
Data Source: Reactome,STRINGDB
PROS1
Tbio
Novelty: 0.00275184
Score: 0.973
Data Source: Reactome,STRINGDB
F2
Tclin
Family: Enzyme
Novelty: 0.00004833
Score: 0.971
Data Source: Reactome,STRINGDB
F10
Tclin
Family: Enzyme
Novelty: 0.00063008
Score: 0.959
Data Source: Reactome,STRINGDB
PROC
Tchem
Family: Enzyme
Novelty: 0.00440723
Score: 0.95
Data Source: Reactome,STRINGDB
GAS6
Tbio
Novelty: 0.00297606
Score: 0.943
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  110.91

PubMed score by year
PubTator Score  92.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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