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Tchem
APOB
Apolipoprotein B-100

Protein Summary
Description
Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
metabolite
1
protein domain
1
biological process
0.98
trait
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12182.47   (req: < 5)
Gene RIFs: 506   (req: <= 3)
Antibodies: 1048   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12182.47   (req: >= 5)
Gene RIFs: 506   (req: > 3)
Antibodies: 1048   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 49
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
21
24
55
4.2
99.9
total cholesterol measurement
11
20
44
3.8
99.6
triglyceride measurement
8
9
23
6
98.9
high density lipoprotein cholesterol measurement
7
7
18
98.5
metabolic syndrome
2
1
2
86.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
55
4.2
99.9
total cholesterol measurement
44
3.8
99.6
triglyceride measurement
23
6
98.9
high density lipoprotein cholesterol measurement
18
98.5
metabolic syndrome
2
86.9
Pathways (53)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

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Items per page:
1 – 5 of 42
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Cell surface interactions at the vascular wall
Reactome
Chylomicron assembly
Reactome
Chylomicron clearance
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Cargo recognition for clathrin-mediated endocytosis
Cell surface interactions at the vascular wall
Chylomicron assembly
Chylomicron clearance
Gene Ontology Terms (72)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Protein-Protein Interactions (578)
1 – 10 of 578
RPN2
Tbio
Family: Enzyme
Novelty: 0.01796569
p_int: 0.984217839
p_ni: 0.015782161
Data Source: BioPlex
YIPF3
Tbio
Novelty: 0.12021667
p_int: 0.983956843
p_ni: 0.016043005
p_wrong: 1.52e-7
Data Source: BioPlex
LITAF
Tbio
Family: TF
Novelty: 0.0097203
p_int: 0.978465593
p_ni: 0.021534407
Data Source: BioPlex
TMEM128
Tdark
Novelty: 5.15874803
p_int: 0.969848017
p_ni: 0.030151983
Data Source: BioPlex
ZFYVE27
Tbio
Novelty: 0.0563358
p_int: 0.959199115
p_ni: 0.040800882
p_wrong: 2e-9
Data Source: BioPlex
ZDHHC11
Tdark
Family: Enzyme
Novelty: 0.35249931
p_int: 0.956770367
p_ni: 0.043229632
Score: 0.177
Data Source: BioPlex,STRINGDB
SLC37A3
Tdark
Family: Transporter
Novelty: 0.21571546
p_int: 0.934312432
p_ni: 0.065684641
p_wrong: 0.000002926
Data Source: BioPlex
AUP1
Tbio
Novelty: 0.0418459
p_int: 0.878641691
p_ni: 0.121358305
p_wrong: 4e-9
Score: 0.545
Data Source: BioPlex,STRINGDB
SSR3
Tbio
Novelty: 0.05838475
p_int: 0.876032728
p_ni: 0.123095459
p_wrong: 0.000871813
Data Source: BioPlex
RTP2
Tbio
Novelty: 0.05972678
p_int: 0.875653065
p_ni: 0.123511313
p_wrong: 0.000835622
Data Source: BioPlex
Publication Statistics
PubMed Score  12182.47

PubMed score by year
PubTator Score  8443.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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