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Tbio
WDFY1
WD repeat and FYVE domain-containing protein 1

Protein Summary
Description
Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436). The protein encoded by this gene is a phosphatidylinositol 3-phosphate binding protein, which contains a FYVE zinc finger domain and multiple WD-40 repeat domains. When exogenously expressed, it localizes to early endosomes. Mutagenesis analysis demonstrates that this endosomal localization is mediated by the FYVE domain. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233055
  • ENSP00000233055
  • ENSG00000085449

Symbol
  • FENS1
  • KIAA1435
  • WDF1
  • ZFYVE17
  • WDF1
  • FENS1
  • FENS-1
  • ZFYVE17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
kinase perturbation
0.98
transcription factor perturbation
0.94
gene perturbation
0.86
interacting protein
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.49   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.49   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
46.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
46.8
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (67)
1 – 10 of 67
VAMP3
Tbio
Novelty: 0.00694332
p_int: 0.999962471
p_ni: 0.000037523
p_wrong: 6e-9
Data Source: BioPlex
KCTD21
Tbio
Novelty: 1.05252269
p_int: 0.999958216
p_ni: 0.000041764
p_wrong: 2e-8
Score: 0.167
Data Source: BioPlex,STRINGDB
SIRT5
Tchem
Family: Epigenetic
Novelty: 0.00225239
p_int: 0.999739648
p_ni: 0.000260346
p_wrong: 6e-9
Score: 0.249
Data Source: BioPlex,STRINGDB
CCDC88C
Tbio
Novelty: 0.0495648
p_int: 0.999532011
p_ni: 0.000467989
Score: 0.205
Data Source: BioPlex,STRINGDB
TMEM123
Tbio
Novelty: 0.13780869
p_int: 0.999384367
p_ni: 0.000615578
p_wrong: 5.5e-8
Score: 0.338
Data Source: BioPlex,STRINGDB
CCNB2
Tbio
Novelty: 0.00672914
p_int: 0.99898247
p_ni: 0.001017037
p_wrong: 4.92e-7
Score: 0.334
Data Source: BioPlex,STRINGDB
NUDT1
Tchem
Family: Enzyme
Novelty: 0.00383386
p_int: 0.998806585
p_ni: 0.001191747
p_wrong: 0.000001668
Data Source: BioPlex
RYDEN
Tdark
Novelty: 0.17308437
p_int: 0.998630723
p_ni: 0.001369232
p_wrong: 4.5e-8
Data Source: BioPlex
MYLIP
Tbio
Family: Enzyme
Novelty: 0.00836935
p_int: 0.995791948
p_ni: 0.004203903
p_wrong: 0.000004149
Score: 0.188
Data Source: BioPlex,STRINGDB
ATG14
Tbio
Novelty: 0.00914791
p_int: 0.995656775
p_ni: 0.004343162
p_wrong: 6.3e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  9.49

PubMed score by year
PubTator Score  3.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer