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Tbio
IL4
Interleukin-4

Protein Classes
Protein Summary
Description
Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (By similarity). The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231449
  • ENSP00000231449
  • ENSG00000113520
  • ENST00000350025
  • ENSP00000325190

Symbol
  • BSF1
  • IL-4
  • BCGF1
  • BSF-1
  • BCGF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
co-expressed gene
0.89
disease
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9500.76   (req: < 5)
Gene RIFs: 779   (req: <= 3)
Antibodies: 1683   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9500.76   (req: >= 5)
Gene RIFs: 779   (req: > 3)
Antibodies: 1683   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (27)
1 – 5 of 27
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (56)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-18 signaling
Reactome
Interleukin-4 and Interleukin-13 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-18 signaling
Interleukin-4 and Interleukin-13 signaling
Protein-Protein Interactions (685)
1 – 10 of 685
IL4R
Tclin
Novelty: 0.00547841
Score: 0.999
Data Source: Reactome,STRINGDB
STAT6
Tchem
Family: TF
Novelty: 0.00118956
Score: 0.997
Data Source: Reactome,STRINGDB
IL2RG
Tclin
Novelty: 0.00155443
Score: 0.996
Data Source: Reactome,STRINGDB
IL6
Tclin
Novelty: 0.00002829
Score: 0.996
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00009183
Score: 0.992
Data Source: STRINGDB
TNF
Tclin
Novelty: 0.00001974
Score: 0.992
Data Source: STRINGDB
IL13RA1
Tbio
Novelty: 0.03405858
Score: 0.992
Data Source: Reactome,STRINGDB
IL1B
Tclin
Novelty: 0.00003644
Score: 0.991
Data Source: STRINGDB
CCL2
Tchem
Novelty: 0.00013411
Score: 0.991
Data Source: STRINGDB
IL18
Tbio
Novelty: 0.00038161
Score: 0.986
Data Source: STRINGDB
Publication Statistics
PubMed Score  9500.76

PubMed score by year
PubTator Score  6709.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFC
1-70
RAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERL
70-140
KTIMREKYSKCSS
140-153
MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS