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Tbio
STK38
Serine/threonine-protein kinase 38

Protein Classes
Protein Summary
Description
Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2. This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229812
  • ENSP00000229812
  • ENSG00000112079

Symbol
  • NDR1
  • NDR
  • NDR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
protein domain
0.92
interacting protein
0.9
disease perturbation
0.87
PubMedID
0.84


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.9   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 412   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.9   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 412   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
4
5
95.1
platelet count
2
2
2
82.3
airway imaging measurement
1
1
1
26.1
mean corpuscular volume
1
1
1
5.2
cup-to-disc ratio measurement
1
1
1
5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
95.1
platelet count
2
82.3
airway imaging measurement
1
26.1
mean corpuscular volume
1
5.2
cup-to-disc ratio measurement
1
5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 38
VGNC:3712
462647
Macaque
serine/threonine kinase 38
719169
Mouse
MGI:2442572
106504
Dog
serine/threonine kinase 38
VGNC:46919
481766
Horse
serine/threonine kinase 38
VGNC:49342
100063891
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 38
Macaque
serine/threonine kinase 38
Mouse
Dog
serine/threonine kinase 38
Horse
serine/threonine kinase 38
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15208-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Interactome of polycomb repressive complex 2 (PRC2)
Name
Explore in Pharos
Explore in Source
Interactome of polycomb repressive complex 2 (PRC2)
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (81)
1 – 10 of 81
MOB2
Tbio
Family: Enzyme
Novelty: 0.02691673
p_int: 1
Score: 0.912
Data Source: BioPlex,STRINGDB
MARVELD2
Tbio
Novelty: 0.01228406
p_int: 0.999999467
p_ni: 5.25e-7
p_wrong: 8e-9
Score: 0.269
Data Source: BioPlex,STRINGDB
MOB1B
Tbio
Family: Enzyme
Novelty: 0.0718959
p_int: 0.999999446
p_ni: 5.52e-7
p_wrong: 1e-9
Score: 0.895
Data Source: BioPlex,STRINGDB
LAMTOR5
Tbio
Novelty: 0.003692
p_int: 0.999942954
p_ni: 0.000057045
p_wrong: 1e-9
Data Source: BioPlex
S100B
Tchem
Novelty: 0.00031007
Score: 0.944
Data Source: STRINGDB
MOB1A
Tbio
Family: Enzyme
Novelty: 0.01430129
Score: 0.924
Data Source: STRINGDB
MOB3A
Tdark
Family: Enzyme
Novelty: 0.94196299
Score: 0.767
Data Source: STRINGDB
FRY
Tbio
Novelty: 0.14352873
Score: 0.761
Data Source: STRINGDB
FRYL
Tdark
Novelty: 0.13893531
Score: 0.761
Data Source: STRINGDB
DIS3L2
Tbio
Family: Enzyme
Novelty: 0.03132063
Score: 0.709
Data Source: STRINGDB
Publication Statistics
PubMed Score  35.90

PubMed score by year
PubTator Score  103.58

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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