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Tbio
COX6A1
Cytochrome c oxidase subunit 6A1, mitochondrial

Protein Summary
Description
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that there may be several pseudogenes on chromos ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229379
  • ENSP00000229379
  • ENSG00000111775

Symbol
  • COX6AL
  • COX6A
  • CMTRID
  • COX6AL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.98
co-expressed gene
0.89
transcription factor binding site profile
0.79
cellular component
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.99   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 284   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.99   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (19)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
RNA Polymerase II Transcription
Reactome
Respiratory electron transport
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
RNA Polymerase II Transcription
Respiratory electron transport
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (138)
1 – 10 of 138
COX6B1
Tbio
Family: Enzyme
Novelty: 0.02531055
p_int: 0.999999595
p_ni: 4.04e-7
p_wrong: 1e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
DNAJC6
Tbio
Family: Enzyme
Novelty: 0.01359669
p_int: 0.99993871
p_ni: 0.00006129
Data Source: BioPlex
COX6C
Tbio
Family: Enzyme
Novelty: 0.04365165
p_int: 0.999575623
p_ni: 0.000424377
Score: 0.995
Data Source: BioPlex,STRINGDB
COX7A2
Tbio
Family: Enzyme
Novelty: 0.04287864
p_int: 0.999062967
p_ni: 0.000439417
p_wrong: 0.000497616
Score: 0.946
Data Source: BioPlex,STRINGDB
UQCRB
Tbio
Novelty: 0.02933046
p_int: 0.998770787
p_ni: 0.001229213
Score: 0.972
Data Source: BioPlex,STRINGDB
COX7A2L
Tbio
Family: Enzyme
Novelty: 0.06920916
p_int: 0.998599826
p_ni: 0.001399731
p_wrong: 4.43e-7
Score: 0.977
Data Source: BioPlex,STRINGDB
DHRS4
Tbio
Family: Enzyme
Novelty: 0.02992279
p_int: 0.998469287
p_ni: 0.001530712
p_wrong: 1e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
MT-CO1
Tchem
Family: Enzyme
Novelty: 0.00008262
p_int: 0.994598157
p_ni: 0.005401843
Score: 0.983
Data Source: BioPlex,STRINGDB
COX5B
Tbio
Family: Enzyme
Novelty: 0.01729026
p_int: 0.994182357
p_ni: 0.005817643
Score: 0.999
Data Source: BioPlex,STRINGDB
UQCRQ
Tbio
Novelty: 0.04392627
p_int: 0.970024143
p_ni: 0.029918387
p_wrong: 0.00005747
Score: 0.992
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  16.99

PubMed score by year
PubTator Score  8.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer