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Tbio
TPI1
Triosephosphate isomerase

Protein Classes
Protein Summary
Description
This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229270
  • ENSP00000229270
  • ENSG00000111669
  • ENST00000396705
  • ENSP00000379933
  • ENST00000488464
  • ENSP00000475620
  • ENST00000535434
  • ENSP00000443599
  • ENST00000613953
  • ENSP00000484435

Symbol
  • TPI
  • TIM
  • TPI
  • TPID
  • HEL-S-49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
protein complex
0.98
virus perturbation
0.94
interacting protein
0.92
kinase perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1333.62   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 437   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1333.62   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 437   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (17)
1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (21)
Gluconeogenesis (R-HSA-70263)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Gluconeogenesis
Glucose metabolism
Glycolysis
Metabolism
Metabolism of carbohydrates
Protein-Protein Interactions (486)
1 – 10 of 486
GPI
Tbio
Family: Enzyme
Novelty: 0.00095404
Score: 0.999
Data Source: STRINGDB
PGK1
Tchem
Family: Kinase
Novelty: 0.00113494
Score: 0.999
Data Source: STRINGDB
GAPDH
Tchem
Family: Enzyme
Novelty: 0.00005849
Score: 0.999
Data Source: STRINGDB
ENO1
Tchem
Family: Enzyme
Novelty: 0.00109178
Score: 0.996
Data Source: STRINGDB
GAPDHS
Tbio
Family: Enzyme
Novelty: 0.00885959
Score: 0.995
Data Source: STRINGDB
PGK2
Tbio
Family: Kinase
Novelty: 0.00832045
Score: 0.994
Data Source: STRINGDB
ALDOA
Tbio
Family: Enzyme
Novelty: 0.00517474
Score: 0.99
Data Source: STRINGDB
TKT
Tchem
Family: Enzyme
Novelty: 0.00333936
Score: 0.984
Data Source: STRINGDB
ALDOC
Tbio
Family: Enzyme
Novelty: 0.01552954
Score: 0.983
Data Source: STRINGDB
ALDOB
Tbio
Family: Enzyme
Novelty: 0.00856695
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  1333.62

PubMed score by year
PubTator Score  801.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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