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Tclin
IFNG
Interferon gamma

Protein Classes
Protein Summary
Description
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229135
  • ENSP00000229135
  • ENSG00000111537

Symbol
  • IFG
  • IFI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
phenotype
1
disease
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6290.62   (req: < 5)
Gene RIFs: 1371   (req: <= 3)
Antibodies: 2944   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6290.62   (req: >= 5)
Gene RIFs: 1371   (req: > 3)
Antibodies: 2944   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
emapalumab
no chemical structure image available
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (97)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Gene Ontology Terms (54)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (549)
1 – 10 of 549
IFNGR1
Tbio
Novelty: 0.00552398
p_int: 0.944341014
p_ni: 0.055658986
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
GOPC
Tbio
Novelty: 0.0164207
p_int: 0.920643046
p_ni: 0.079356954
Score: 0.189
Data Source: BioPlex,STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.00041067
Score: 0.989
Data Source: Reactome,STRINGDB
FOXP3
Tbio
Family: TF
Novelty: 0.00020363
Score: 0.986
Data Source: STRINGDB
IRF1
Tbio
Family: TF
Novelty: 0.00077466
Score: 0.98
Data Source: STRINGDB
TNF
Tclin
Novelty: 0.00001974
Score: 0.975
Data Source: STRINGDB
STAT4
Tbio
Family: TF
Novelty: 0.00296176
Score: 0.971
Data Source: STRINGDB
IFNGR2
Tbio
Novelty: 0.01863002
Score: 0.968
Data Source: Reactome,STRINGDB
SOCS3
Tbio
Novelty: 0.00082008
Score: 0.962
Data Source: Reactome,STRINGDB
RELA
Tchem
Family: TF
Novelty: 0.00091233
Score: 0.959
Data Source: STRINGDB
Publication Statistics
PubMed Score  6290.62

PubMed score by year
PubTator Score  16981.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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