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Tbio
IL26
Interleukin-26

Protein Summary
Description
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229134
  • ENSP00000229134
  • ENSG00000111536

Symbol
  • AK155
  • AK155
  • IL-26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.75
protein domain
0.73
cell line
0.52
disease
0.46
trait
0.46


Related Tools
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.89   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.89   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 26
VGNC:13152
741377
Macaque
interleukin 26
718027
Platypus
interleukin 26
100080300
Xenopus
interleukin 22
XB-GENE-490272
100192370
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 26
Macaque
interleukin 26
Platypus
interleukin 26
Xenopus
interleukin 22
Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-20 family signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-20 family signaling
Signaling by Interleukins
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (45)
1 – 10 of 45
IL20RA
Tbio
Novelty: 0.02416816
Score: 0.969
Data Source: Reactome,STRINGDB
IL10RB
Tbio
Novelty: 0.00880915
Score: 0.969
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.949
Data Source: Reactome,STRINGDB
TYK2
Tclin
Family: Kinase
Novelty: 0.00237955
Score: 0.944
Data Source: Reactome,STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.0003383
Score: 0.941
Data Source: Reactome,STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.939
Data Source: Reactome,STRINGDB
IL19
Tbio
Novelty: 0.0075728
Score: 0.79
Data Source: STRINGDB
IL22
Tbio
Novelty: 0.0023754
Score: 0.764
Data Source: STRINGDB
IL24
Tbio
Novelty: 0.00225887
Score: 0.738
Data Source: STRINGDB
IL17F
Tbio
Novelty: 0.00223549
Score: 0.733
Data Source: STRINGDB
Publication Statistics
PubMed Score  81.89

PubMed score by year
PubTator Score  42.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer