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Tbio
MGP
Matrix Gla protein

Protein Summary
Description
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228938
  • ENSP00000228938
  • ENSG00000111341
  • ENST00000539261
  • ENSP00000445907

Symbol
  • MGLAP
  • NTI
  • GIG36
  • MGLAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
disease
0.85
small molecule perturbation
0.85
disease perturbation
0.83
kinase perturbation
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 881.09   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 881.09   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
matrix Gla protein
VGNC:13251
465310
Mouse
MGI:96976
17313
Rat
RGD:3088
25333
Horse
matrix Gla protein
VGNC:20164
100063934
Opossum
matrix Gla protein
100013120
Species
Name
OMA
EggNOG
Inparanoid
Chimp
matrix Gla protein
Mouse
Rat
Horse
matrix Gla protein
Opossum
matrix Gla protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P08493-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Name
Explore in Pharos
Explore in Source
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Protein-Protein Interactions (66)
1 – 10 of 66
PTH
Tbio
Novelty: 0.00003263
Score: 0.754
Data Source: STRINGDB
AHSG
Tbio
Novelty: 0.00112502
Score: 0.749
Data Source: STRINGDB
BGLAP
Tbio
Novelty: 0.00009678
Score: 0.734
Data Source: STRINGDB
BMP2
Tbio
Novelty: 0.00016974
Score: 0.733
Data Source: STRINGDB
SPP1
Tbio
Novelty: 0.00014418
Score: 0.709
Data Source: STRINGDB
GGCX
Tclin
Family: Enzyme
Novelty: 0.00819484
Score: 0.705
Data Source: STRINGDB
PROS1
Tbio
Novelty: 0.00275184
Score: 0.679
Data Source: STRINGDB
TNFRSF11B
Tbio
Novelty: 0.00581698
Score: 0.675
Data Source: STRINGDB
OPRM1
Tclin
Family: GPCR
Novelty: 0.0003701
Score: 0.669
Data Source: STRINGDB
OPRK1
Tclin
Family: GPCR
Novelty: 0.00171044
Score: 0.642
Data Source: STRINGDB
Publication Statistics
PubMed Score  881.09

PubMed score by year
PubTator Score  397.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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