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Tbio
OAS3
2'-5'-oligoadenylate synthase 3

Protein Summary
Description
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228928
  • ENSP00000228928
  • ENSG00000111331

Symbol
  • p100
  • p100OAS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
molecular function
0.96
histone modification site profile
0.75
gene perturbation
0.73
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.53   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.53   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
1
1
0
1.6
79.2
alcohol drinking
1
1
0
1.6
79.2
high density lipoprotein cholesterol measurement
1
1
0
1.4
68.7
1
1
0
1.2
21.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
0
1.6
79.2
alcohol drinking
0
1.6
79.2
high density lipoprotein cholesterol measurement
0
1.4
68.7
0
1.2
21.7
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y6K5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Protein-Protein Interactions (205)
1 – 10 of 205
ISG15
Tbio
Novelty: 0.00203781
Score: 0.994
Data Source: STRINGDB
MX1
Tbio
Novelty: 0.00072554
Score: 0.993
Data Source: STRINGDB
IFIT1
Tbio
Novelty: 0.00562299
Score: 0.993
Data Source: STRINGDB
IFIT3
Tbio
Novelty: 0.00568113
Score: 0.992
Data Source: STRINGDB
IFI6
Tbio
Novelty: 0.02590679
Score: 0.992
Data Source: STRINGDB
RSAD2
Tbio
Novelty: 0.0056473
Score: 0.99
Data Source: STRINGDB
IFI35
Tbio
Novelty: 0.04309126
Score: 0.989
Data Source: STRINGDB
MX2
Tbio
Novelty: 0.00139073
Score: 0.988
Data Source: STRINGDB
IFIT2
Tbio
Novelty: 0.01023074
Score: 0.985
Data Source: STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.0021839
Score: 0.984
Data Source: STRINGDB
Publication Statistics
PubMed Score  36.53

PubMed score by year
PubTator Score  879.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer