Tbio KITLG Kit ligand

Protein Summary

Description

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P21583
• A0AV09
• A8K2Q4
• B7ZLM4
• Q16487
• Q68DZ2
• Q7M4N8
• Q9UQK7

Gene Name

• KITLG

Ensembl ID

• ENST00000228280
• ENSP00000228280
• ENSG00000049130
• ENST00000347404
• ENSP00000054216
• ENST00000644744
• ENSP00000495951

Symbol

• MGF
• SCF
• SF
• MGF
• SCF
• SLF
• DCUA
• FPH2
• FPHH
• KL-1
• Kitl
• SHEP7
• DFNA69

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
biological process	0.97
biological term	0.97
gene perturbation	0.91
PubMedID	0.82

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1922.18   (req: < 5)

Gene RIFs: 171   (req: <= 3)

Antibodies: 828   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1922.18   (req: >= 5)

Gene RIFs: 171   (req: > 3)

Antibodies: 828   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (3)

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (91)

Reactome (20)

KEGG (8)

PathwayCommons (11)

WikiPathways (52)

Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)

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Items per page:

5

1 – 5 of 20

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Constitutive Signaling by Aberrant PI3K in Cancer	75 targets	R-HSA-2219530
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases of signal transduction	387 targets	R-HSA-5663202
Reactome	FLT3 Signaling	264 targets	R-HSA-9607240

Name	Explore in Pharos	Explore in Source
Constitutive Signaling by Aberrant PI3K in Cancer	75 targets	R-HSA-2219530
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Disease	1105 targets	R-HSA-1643685
Diseases of signal transduction	387 targets	R-HSA-5663202
FLT3 Signaling	264 targets	R-HSA-9607240

Gene Ontology Terms (34)

Functions (5)

Components (8)

Processes (21)

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Traceable Author Statement (TAS)	Reactome
Ras guanyl-nucleotide exchange factor activity	Traceable Author Statement (TAS)	Reactome
stem cell factor receptor binding	Traceable Author Statement (TAS)	ProtInc
cytokine activity	Inferred from Electronic Annotation (IEA)	Ensembl
growth factor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (302)

Explore Interacting Targets

1 – 10 of 302

• See Interactions on String-DB

KLHDC10

Tdark

Novelty: 0.60606061

p_int: 0.999962722

p_ni: 0.00003727

p_wrong: 8e-9

Score: 0.455

Data Source: BioPlex,STRINGDB

ATP8B2

Tdark

Family: Transporter

Novelty: 0.20856013

p_int: 0.985642839

p_ni: 0.014357161

Score: 0.534

Data Source: BioPlex,STRINGDB

SLC22A18

Tbio

Family: Transporter

Novelty: 0.00369458

p_int: 0.864467356

p_ni: 0.135388639

p_wrong: 0.000144005

Score: 0.2

Data Source: BioPlex,STRINGDB

KIT

Tclin

Family: Kinase

Novelty: 0.00013951

Score: 0.999

Data Source: Reactome,STRINGDB

EPO

Tbio

Novelty: 0.00017234

Score: 0.984

Data Source: STRINGDB

EPOR

Tclin

Novelty: 0.00150259

Score: 0.97

Data Source: STRINGDB

PDGFRB

Tclin

Family: Kinase

Novelty: 0.00115144

Score: 0.967

Data Source: STRINGDB

STAT3

Tchem

Family: TF

Novelty: 0.00013496

Score: 0.966

Data Source: Reactome,STRINGDB

MATK

Tbio

Family: Kinase

Novelty: 0.00103714

Score: 0.957

Data Source: STRINGDB

FLT3

Tclin

Family: Kinase

Novelty: 0.00045788

Score: 0.948

Data Source: STRINGDB

Publication Statistics

PubMed Score  1922.18

PubMed score by year

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PubTator Score  2278.54

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MKKTQTWILTCIYLQLLLFNPLVKTEGICRNRVTNNVKDVTKLVANLPKDYMITLKYVPGMDVLPSHCWI

1-70

SEMVVQLSDSLTDLLDKFSNISEGLSNYSIIDKLVNIVDDLVECVKENSSKDLKKSFKSPEPRLFTPEEF

70-140

FRIFNRSIDAFKDFVVASETSDCVVSSTLSPEKDSRVSVTKPFMLPPVAASSLRNDSSSSNRKAKNPPGD

140-210

SSLHWAAMALPALFSLIIGFAFGALYWKKRQPSLTRAVENIQINEEDNEISMLQEKEREFQEV

210-273

MKKTQTWILTCIYLQLLLFNPLVKTEGICRNRVTNNVKDVTKLVANLPKDYMITLKYVPGMDVLPSHCWISEMVVQLSDSLTDLLDKFSNISEGLSNYSIIDKLVNIVDDLVECVKENSSKDLKKSFKSPEPRLFTPEEFFRIFNRSIDAFKDFVVASETSDCVVSSTLSPEKDSRVSVTKPFMLPPVAASSLRNDSSSSNRKAKNPPGDSSLHWAAMALPALFSLIIGFAFGALYWKKRQPSLTRAVENIQINEEDNEISMLQEKEREFQEV

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Uniprot Keyword

3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Deafness
Direct protein sequencing