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Tbio
SPI1
Transcription factor PU.1

Protein Summary
Description
Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227163
  • ENSP00000227163
  • ENSG00000066336
  • ENST00000378538
  • ENSP00000367799

Symbol
  • OF
  • PU.1
  • SFPI1
  • SPI-1
  • SPI-A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
molecular function
0.98
hub protein
0.79
biological term
0.76
tissue sample
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1707.12   (req: < 5)
Gene RIFs: 161   (req: <= 3)
Antibodies: 501   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1707.12   (req: >= 5)
Gene RIFs: 161   (req: > 3)
Antibodies: 501   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
2
81.7
alcohol consumption measurement
1
1
1
80.9
worry measurement
1
2
2
69.2
intraocular pressure measurement
1
1
1
68.2
cognitive function measurement
1
1
1
50.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
81.7
alcohol consumption measurement
1
80.9
worry measurement
2
69.2
intraocular pressure measurement
1
68.2
cognitive function measurement
1
50.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:98282
20375
Rat
RGD:1359607
366126
Dog
Spi-1 proto-oncogene
VGNC:52051
611255
Horse
Spi-1 proto-oncogene
VGNC:23519
100051397
Cow
Spi-1 proto-oncogene
VGNC:35213
507100
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
Spi-1 proto-oncogene
Horse
Spi-1 proto-oncogene
Cow
Spi-1 proto-oncogene
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P17947-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (30)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Gene Ontology Terms (38)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (444)
1 – 10 of 444
CSF1R
Tclin
Family: Kinase
Novelty: 0.00064143
Score: 0.988
Data Source: STRINGDB
RUNX1
Tbio
Family: TF
Novelty: 0.0085181
Score: 0.978
Data Source: STRINGDB
FLT3
Tclin
Family: Kinase
Novelty: 0.0003477
Score: 0.969
Data Source: STRINGDB
GATA1
Tbio
Family: TF
Novelty: 0.00077901
Score: 0.963
Data Source: STRINGDB
ITGAM
Tbio
Novelty: 0.00017521
Score: 0.963
Data Source: STRINGDB
IRF8
Tbio
Family: TF
Novelty: 0.00330143
Score: 0.963
Data Source: STRINGDB
TBP
Tbio
Novelty: 0.00034941
Score: 0.958
Data Source: STRINGDB
RB1
Tchem
Novelty: 0.00063798
Score: 0.949
Data Source: STRINGDB
FCGR1A
Tchem
Novelty: 0.00073204
Score: 0.942
Data Source: STRINGDB
E2F3
Tbio
Family: TF
Novelty: 0.00287552
Score: 0.94
Data Source: STRINGDB
Publication Statistics
PubMed Score  1707.12

PubMed score by year
PubTator Score  479.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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