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Tbio
CD82
CD82 antigen

Protein Summary
Description
Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway. This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227155
  • ENSP00000227155
  • ENSG00000085117
  • ENST00000342935
  • ENSP00000339686

Symbol
  • KAI1
  • SAR2
  • ST6
  • TSPAN27
  • R2
  • 4F9
  • C33
  • IA4
  • ST6
  • GR15
  • KAI1
  • SAR2
  • TSPAN27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.84
transcription factor binding site profile
0.8
gene perturbation
0.74
transcription factor perturbation
0.74
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 712.73   (req: < 5)
Gene RIFs: 146   (req: <= 3)
Antibodies: 543   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 712.73   (req: >= 5)
Gene RIFs: 146   (req: > 3)
Antibodies: 543   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
3
3
78.8
lymphocyte count
2
1
2
60.4
reticulocyte measurement
2
1
2
42.8
reticulocyte count
2
1
2
41.3
mean reticulocyte volume
1
1
1
27
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
78.8
lymphocyte count
2
60.4
reticulocyte measurement
2
42.8
reticulocyte count
2
41.3
mean reticulocyte volume
1
27
Gene Ontology Terms (4)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (95)
1 – 10 of 95
NAT8B
Tbio
Family: Enzyme
p_int: 0.999766475
p_ni: 5e-9
p_wrong: 0.00023352
Data Source: BioPlex
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.782
Data Source: STRINGDB
TSG101
Tbio
Novelty: 0.00211746
Score: 0.742
Data Source: STRINGDB
TPMT
Tchem
Family: Enzyme
Novelty: 0.00272111
Score: 0.737
Data Source: STRINGDB
ST5
Tbio
Novelty: 0.0046113
Score: 0.715
Data Source: STRINGDB
VANGL1
Tbio
Novelty: 0.00968008
Score: 0.714
Data Source: STRINGDB
IGSF8
Tbio
Novelty: 0.03016623
Score: 0.709
Data Source: STRINGDB
PTGFRN
Tbio
Novelty: 0.02271483
Score: 0.694
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.692
Data Source: STRINGDB
CDH1
Tbio
Novelty: 0.00010629
Score: 0.67
Data Source: STRINGDB
Publication Statistics
PubMed Score  712.73

PubMed score by year
PubTator Score  451.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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