Protein Classes
Protein Summary
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24315.1 (req: < 5)
Gene RIFs: 488 (req: <= 3)
Antibodies: 1832 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24315.1 (req: >= 5)
Gene RIFs: 488 (req: > 3)
Antibodies: 1832 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 45
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 16
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (16)
1 – 10 of 16
Protein Data Bank (24)
1 – 5 of 24
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (71)
Reactome (18)
KEGG (19)
PathwayCommons (15)
WikiPathways (19)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 18
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | FLT3 Signaling | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
FLT3 Signaling | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Immune System | ||||
Gene Ontology Terms (48)
Functions (8)
Components (3)
Processes (37)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | MGI | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (762)
1 – 10 of 762
IL17A
Novelty: 0.00018525
p_int: 0.999999999
p_ni: 1e-9
Score: 0.982
Data Source: BioPlex,STRINGDB
IL2RA
Novelty: 0.0009569
Score: 0.999
Data Source: Reactome,STRINGDB
IL2RG
Novelty: 0.00155443
Score: 0.997
Data Source: Reactome,STRINGDB
FOXP3
Family: TF
Novelty: 0.00020363
Score: 0.997
Data Source: STRINGDB
IL2RB
Novelty: 0.00753505
Score: 0.996
Data Source: Reactome,STRINGDB
IL5
Novelty: 0.00032832
Score: 0.995
Data Source: STRINGDB
CSF2
Novelty: 0.00012299
Score: 0.994
Data Source: STRINGDB
STAT5A
Family: TF
Novelty: 0.00091229
Score: 0.991
Data Source: STRINGDB
STAT5B
Family: TF
Novelty: 0.00091216
Score: 0.991
Data Source: STRINGDB
IL3
Novelty: 0.00031085
Score: 0.989
Data Source: STRINGDB
Publication Statistics
PubMed Score 24315.10
PubMed score by year
PubTator Score 17629.1
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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