Pharos: Interleukin-2 (Tchem)

Tchem

Protein Classes

Protein Summary

Description

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

Gene Name

Ensembl ID

ENST00000226730
ENSP00000226730
ENSG00000109471

Symbol

IL-2
TCGF
lymphokine

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1

biological term	1

chemical	1

disease	0.87

molecular function	0.79

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24315.1 (req: < 5)

View Publications

Gene RIFs: 488 (req: <= 3)

View Gene RIFs

Antibodies: 1832 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24315.1 (req: >= 5)

Gene RIFs: 488 (req: > 3)

Antibodies: 1832 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16

Explore Active Ligands

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (16)

1 – 10 of 16

Protein Data Bank (24)

1 – 5 of 24

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (71)

Reactome (18)

KEGG (19)

PathwayCommons (15)

WikiPathways (19)

Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 18

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Reactome	FLT3 Signaling	264 targets	R-HSA-9607240

Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160

Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436

Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

FLT3 Signaling	264 targets	R-HSA-9607240

Gene expression (Transcription)	1452 targets	R-HSA-74160

Generic Transcription Pathway	1195 targets	R-HSA-212436

Immune System	2246 targets	R-HSA-168256

Gene Ontology Terms (48)

Functions (8)

Components (3)

Processes (37)

Items per page:

1 – 8 of 8

GO Term	Evidence	Assigned by
cytokine activity	Inferred from Direct Assay (IDA)	MGI

interleukin-2 receptor binding	Inferred from Direct Assay (IDA)	MGI

growth factor activity	Traceable Author Statement (TAS)	UniProtKB

kinase activator activity	Traceable Author Statement (TAS)	UniProtKB

Ras guanyl-nucleotide exchange factor activity	Traceable Author Statement (TAS)	Reactome

carbohydrate binding	Inferred from Electronic Annotation (IEA)	Ensembl

glycosphingolipid binding	Inferred from Electronic Annotation (IEA)	Ensembl

kappa-type opioid receptor binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (762)

1 – 10 of 762

See Interactions on String-DB

IL17A

Tclin

Novelty: 0.00018525

p_int: 0.999999999

p_ni: 1e-9

Score: 0.982

Data Source: BioPlex,STRINGDB

IL2RA

Tclin

Novelty: 0.0009569

Score: 0.999

Data Source: Reactome,STRINGDB

IL2RG

Tclin

Novelty: 0.00155443

Score: 0.997

Data Source: Reactome,STRINGDB

FOXP3

Tbio

Family: TF

Novelty: 0.00020363

Score: 0.997

Data Source: STRINGDB

IL2RB

Tclin

Novelty: 0.00753505

Score: 0.996

Data Source: Reactome,STRINGDB

IL5

Tclin

Novelty: 0.00032832

Score: 0.995

Data Source: STRINGDB

CSF2

Tbio

Novelty: 0.00012299

Score: 0.994

Data Source: STRINGDB

STAT5A

Tchem

Family: TF

Novelty: 0.00091229

Score: 0.991

Data Source: STRINGDB

STAT5B

Tchem

Family: TF

Novelty: 0.00091216

Score: 0.991

Data Source: STRINGDB

IL3

Tbio

Novelty: 0.00031085

Score: 0.989

Data Source: STRINGDB

Publication Statistics

PubMed Score 24315.10

PubMed score by year

PubTator Score 17629.1

PubTator score by year

Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword


3D-structure

Adaptive immunity

Chromosomal rearrangement

Complete proteome

Cytokine

Direct protein sequencing

Disulfide bond

Glycoprotein

Growth factor

Immunity

GWAS Trait

MGI Phenotype


behavior/neurological phenotype

cardiovascular system phenotype

cellular phenotype

digestive/alimentary phenotype

endocrine/exocrine gland phenotype

growth/size/body region phenotype

hematopoietic system phenotype

homeostasis/metabolism phenotype

immune system phenotype

liver/biliary system phenotype


adult onset asthma

age at onset

allergic rhinitis

allergic sensitization measurement

allergy

alopecia areata

asthma

atopic eczema

celiac disease

childhood onset asthma