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Tbio
IBSP
Bone sialoprotein 2

Protein Summary
Description
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226284
  • ENSP00000226284
  • ENSG00000029559

Symbol
  • BNSP
  • BSP
  • BNSP
  • SP-II
  • BSP-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.73
tissue
0.47
small molecule perturbation
0.45
chemical
0.44
disease
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 852.65   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 365   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 852.65   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (28)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Reactome
Integrin cell surface interactions
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Extracellular matrix organization
Integrin cell surface interactions
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
CAFA
Protein-Protein Interactions (136)
1 – 10 of 136
ALPL
Tchem
Family: Enzyme
Novelty: 0.00152281
Score: 0.963
Data Source: STRINGDB
ENPP1
Tchem
Family: Enzyme
Novelty: 0.00256132
Score: 0.941
Data Source: STRINGDB
ITGAV
Tchem
Novelty: 0.00148589
Score: 0.941
Data Source: Reactome,STRINGDB
SPP1
Tbio
Novelty: 0.00014418
Score: 0.925
Data Source: STRINGDB
BGLAP
Tbio
Novelty: 0.00009678
Score: 0.923
Data Source: STRINGDB
ITGB3
Tclin
Novelty: 0.00067255
Score: 0.922
Data Source: Reactome,STRINGDB
COL4A1
Tbio
Novelty: 0.00358049
Score: 0.907
Data Source: STRINGDB
COL4A3
Tbio
Novelty: 0.00296126
Score: 0.904
Data Source: STRINGDB
COL4A2
Tbio
Novelty: 0.00782053
Score: 0.904
Data Source: STRINGDB
COL4A4
Tbio
Novelty: 0.00833684
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  852.65

PubMed score by year
PubTator Score  347.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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