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Tbio
KAT2A
Histone acetyltransferase KAT2A

Protein Summary
Description
Protein lysine acyltransferase that can act both as a acetyltransferase and succinyltransferase, depending on the context (PubMed:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755). Acetylation of histones gives a specific t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225916
  • ENSP00000225916
  • ENSG00000108773

Symbol
  • GCN5
  • GCN5L2
  • GCN5
  • hGCN5
  • GCN5L2
  • PCAF-b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
biological process
0.9
protein domain
0.85
kinase perturbation
0.81
molecular function
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 389.54   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 323   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 389.54   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 323   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
2
46.1
mean reticulocyte volume
1
1
1
35.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
46.1
mean reticulocyte volume
1
35.4
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (54)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 39
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Chromatin modifying enzymes
Chromatin organization
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Gene Ontology Terms (60)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (392)
1 – 10 of 392
MAGEA10
Tbio
Novelty: 0.05364393
p_int: 0.999999952
p_ni: 4.8e-8
Score: 0.257
Data Source: BioPlex,STRINGDB
TAF12
Tbio
Novelty: 0.04352637
p_int: 0.999999466
p_ni: 5.34e-7
Score: 0.983
Data Source: BioPlex,STRINGDB
DR1
Tbio
Novelty: 0.00138571
p_int: 0.99999942
p_ni: 5.8e-7
Score: 0.958
Data Source: BioPlex,STRINGDB
TADA3
Tbio
Novelty: 0.01743814
p_int: 0.999998141
p_ni: 0.000001859
Score: 0.999
Data Source: BioPlex,STRINGDB
MBIP
Tbio
Novelty: 0.05807454
p_int: 0.999997358
p_ni: 0.000002623
p_wrong: 1.9e-8
Score: 0.986
Data Source: BioPlex,STRINGDB
SUPT20H
Tbio
Novelty: 0.00625899
p_int: 0.999989102
p_ni: 0.000010898
Score: 0.994
Data Source: BioPlex,STRINGDB
SGF29
Tbio
Family: Epigenetic
Novelty: 0.0426456
p_int: 0.999966304
p_ni: 0.000033696
Score: 0.998
Data Source: BioPlex,STRINGDB
WDR5
Tchem
Novelty: 0.0059945
p_int: 0.999959555
p_ni: 0.000040445
Score: 0.983
Data Source: BioPlex,STRINGDB
TAF6L
Tdark
Family: Enzyme
Novelty: 0.7411477
p_int: 0.999944457
p_ni: 0.000055543
Score: 0.988
Data Source: BioPlex,STRINGDB
ATXN7L3
Tbio
Novelty: 0.1572083
p_int: 0.999534943
p_ni: 0.000465057
Score: 0.993
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  389.54

PubMed score by year
PubTator Score  181.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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