Protein Classes
Protein Summary
Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases character ...more
- ENST00000225831
- ENSP00000225831
- ENSG00000108691
- MCP1
- SCYA2
- HC11
- MCAF
- MCP1
- MCP-1
- SCYA2
- GDCF-2
- SMC-CF
- HSMCR30
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
gene perturbation | 1 | ||
phenotype | 0.98 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7579.98 (req: < 5)
Gene RIFs: 1119 (req: <= 3)
Antibodies: 1581 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7579.98 (req: >= 5)
Gene RIFs: 1119 (req: > 3)
Antibodies: 1581 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 53
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 22
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (22)
1 – 10 of 22
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (47)
Reactome (9)
KEGG (15)
PathwayCommons (5)
WikiPathways (18)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 9
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | ATF4 activates genes in response to endoplasmic reticulum stress | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-10 signaling | ||||
Reactome | Interleukin-4 and Interleukin-13 signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
ATF4 activates genes in response to endoplasmic reticulum stress | ||||
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Interleukin-10 signaling | ||||
Interleukin-4 and Interleukin-13 signaling | ||||
Gene Ontology Terms (56)
Functions (5)
Components (3)
Processes (48)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (505)
1 – 10 of 505
CCR2
Family: GPCR
Novelty: 0.00080179
Score: 0.997
Data Source: STRINGDB
IL10
Novelty: 0.00007359
Score: 0.995
Data Source: STRINGDB
IL4
Novelty: 0.00010156
Score: 0.991
Data Source: STRINGDB
IL6
Novelty: 0.00002829
Score: 0.982
Data Source: STRINGDB
IL13
Novelty: 0.00043714
Score: 0.981
Data Source: STRINGDB
STAT3
Family: TF
Novelty: 0.00013496
Score: 0.981
Data Source: STRINGDB
CXCL8
Novelty: 0.00009183
Score: 0.98
Data Source: STRINGDB
JUN
Family: TF
Novelty: 0.00013623
Score: 0.978
Data Source: STRINGDB
TNF
Novelty: 0.00001974
Score: 0.971
Data Source: STRINGDB
FOS
Family: TF
Novelty: 0.00007002
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score 7579.98
PubMed score by year
PubTator Score 4395.93
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIV
1-70
AKEICADPKQKWVQDSMDHLDKQTQTPKT
70-99
MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT
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