Tchem CCL2 C-C motif chemokine 2

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / C-c Motif Chemokine 2

DTO Classes

Protein / Signaling / Chemokine / C-c Motif Chemokine 2

Protein Summary

Description

Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• P13500
• B2R4V3
• Q9UDF3

Gene Name

• CCL2

Ensembl ID

• ENST00000225831
• ENSP00000225831
• ENSG00000108691

Symbol

• MCP1
• SCYA2
• HC11
• MCAF
• MCP1
• MCP-1
• SCYA2
• GDCF-2
• SMC-CF
• HSMCR30

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
chemical	1
gene perturbation	1
phenotype	0.98

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7579.98   (req: < 5)

Gene RIFs: 1119   (req: <= 3)

Antibodies: 1581   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7579.98   (req: >= 5)

Gene RIFs: 1119   (req: > 3)

Antibodies: 1581   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 22

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (22)

Explore Active Ligands

1 – 10 of 22

CHEMBL2426341

CCL2Tchem

Kd: 9.64

CHEMBL494019

CCL2Tchem

Ki: 7.3

CHEMBL495368

CCL2Tchem

Ki: 8.17

CHEMBL521697

CCL2Tchem

Ki: 7.51

CHEMBL493780

CCL2Tchem

Ki: 6.96

CHEMBL2426340

CCL2Tchem

Ki: 8.44

CHEMBL2426334

CCL2Tchem

Ki: 8.41

CHEMBL2426333

CCL2Tchem

Ki: 6.89

CHEMBL2426335

CCL2Tchem

Ki: 8.2

CHEMBL2426342

CCL2Tchem

Ki: 6.36

Protein Data Bank (12)

1 – 5 of 12

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (47)

Reactome (9)

KEGG (15)

PathwayCommons (5)

WikiPathways (18)

ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

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Items per page:

5

1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ATF4 activates genes in response to endoplasmic reticulum stress	27 targets	R-HSA-380994
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Interleukin-10 signaling	45 targets	R-HSA-6783783
Reactome	Interleukin-4 and Interleukin-13 signaling	111 targets	R-HSA-6785807

Name	Explore in Pharos	Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress	27 targets	R-HSA-380994
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256
Interleukin-10 signaling	45 targets	R-HSA-6783783
Interleukin-4 and Interleukin-13 signaling	111 targets	R-HSA-6785807

Gene Ontology Terms (56)

Functions (5)

Components (3)

Processes (48)

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
CCR chemokine receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
chemokine activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
CCR2 chemokine receptor binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
protein kinase activity	Traceable Author Statement (TAS)	ProtInc
signaling receptor binding	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (505)

Explore Interacting Targets

1 – 10 of 505

• See Interactions on String-DB

CCR2

Tchem

Family: GPCR

Novelty: 0.00080179

Score: 0.997

Data Source: STRINGDB

IL10

Tbio

Novelty: 0.00007359

Score: 0.995

Data Source: STRINGDB

IL4

Tbio

Novelty: 0.00010156

Score: 0.991

Data Source: STRINGDB

IL6

Tclin

Novelty: 0.00002829

Score: 0.982

Data Source: STRINGDB

IL13

Tbio

Novelty: 0.00043714

Score: 0.981

Data Source: STRINGDB

STAT3

Tchem

Family: TF

Novelty: 0.00013496

Score: 0.981

Data Source: STRINGDB

CXCL8

Tchem

Novelty: 0.00009183

Score: 0.98

Data Source: STRINGDB

JUN

Tchem

Family: TF

Novelty: 0.00013623

Score: 0.978

Data Source: STRINGDB

TNF

Tclin

Novelty: 0.00001974

Score: 0.971

Data Source: STRINGDB

FOS

Tbio

Family: TF

Novelty: 0.00007002

Score: 0.97

Data Source: STRINGDB

Publication Statistics

PubMed Score  7579.98

PubMed score by year

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PubTator Score  4395.93

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIV

1-70

AKEICADPKQKWVQDSMDHLDKQTQTPKT

70-99

MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT

Find similar targets by:

Uniprot Keyword

3D-structure
Chemotaxis
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
Inflammatory response
Pyrrolidone carboxylic acid
Reference proteome