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Tchem
CCL2
C-C motif chemokine 2

Protein Summary
Description
Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases character ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225831
  • ENSP00000225831
  • ENSG00000108691

Symbol
  • MCP1
  • SCYA2
  • HC11
  • MCAF
  • MCP1
  • MCP-1
  • SCYA2
  • GDCF-2
  • SMC-CF
  • HSMCR30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
gene perturbation
1
phenotype
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7579.98   (req: < 5)
Gene RIFs: 1119   (req: <= 3)
Antibodies: 1581   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7579.98   (req: >= 5)
Gene RIFs: 1119   (req: > 3)
Antibodies: 1581   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 22
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (47)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-10 signaling
Reactome
Interleukin-4 and Interleukin-13 signaling
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
Cytokine Signaling in Immune system
Immune System
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Gene Ontology Terms (56)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (505)
1 – 10 of 505
CCR2
Tchem
Family: GPCR
Novelty: 0.00080179
Score: 0.997
Data Source: STRINGDB
IL10
Tbio
Novelty: 0.00007359
Score: 0.995
Data Source: STRINGDB
IL4
Tbio
Novelty: 0.00010156
Score: 0.991
Data Source: STRINGDB
IL6
Tclin
Novelty: 0.00002829
Score: 0.982
Data Source: STRINGDB
IL13
Tbio
Novelty: 0.00043714
Score: 0.981
Data Source: STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00013496
Score: 0.981
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00009183
Score: 0.98
Data Source: STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00013623
Score: 0.978
Data Source: STRINGDB
TNF
Tclin
Novelty: 0.00001974
Score: 0.971
Data Source: STRINGDB
FOS
Tbio
Family: TF
Novelty: 0.00007002
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  7579.98

PubMed score by year
PubTator Score  4395.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIV
1-70
AKEICADPKQKWVQDSMDHLDKQTQTPKT
70-99
MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT