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Tchem
WNT3
Proto-oncogene Wnt-3

Protein Classes
Protein Summary
Description
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development (PubMed:14872406). The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse stu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225512
  • ENSP00000225512
  • ENSG00000108379
  • ENST00000611547
  • ENSP00000478327
  • ENSG00000277626
  • ENST00000616347
  • ENSP00000480990
  • ENSG00000277641

Symbol
  • INT4
  • INT4
  • TETAMS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
trait
0.86
gene perturbation
0.82
PubMedID
0.77
transcription factor
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.32   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 365   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.32   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (48)
Items per page:
1 – 5 of 48
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
91.7
1
1
1
91.7
unipolar depression
1
1
1
91.7
unipolar depression
1
1
1
91.7
neuroticism measurement
2
3
2
6.9
91.1
Items per page:
1 – 5 of 48
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
91.7
1
91.7
unipolar depression
1
91.7
unipolar depression
1
91.7
neuroticism measurement
2
6.9
91.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 3
VGNC:51747
107966366
Macaque
Wnt family member 3
716909
Mouse
MGI:98955
22415
Rat
RGD:3972
24882
Horse
Wnt family member 3
VGNC:49293
100049880
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 3
Macaque
Wnt family member 3
Mouse
Rat
Horse
Wnt family member 3
Pathways (63)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Reactome
Signaling by WNT
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Signaling by WNT
Gene Ontology Terms (39)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (151)
1 – 10 of 151
WNT3A
Tchem
Novelty: 0.00119275
p_int: 1
Score: 0.951
Data Source: BioPlex,STRINGDB
FZD1
Tbio
Family: GPCR
Novelty: 0.01097201
Score: 0.985
Data Source: STRINGDB
FZD7
Tbio
Family: GPCR
Novelty: 0.00916448
Score: 0.983
Data Source: STRINGDB
RYK
Tbio
Family: Kinase
Novelty: 0.00910227
Score: 0.979
Data Source: Reactome,STRINGDB
FZD4
Tchem
Family: GPCR
Novelty: 0.00577957
Score: 0.974
Data Source: STRINGDB
LRP6
Tbio
Novelty: 0.00305615
Score: 0.974
Data Source: STRINGDB
WLS
Tbio
Novelty: 0.01459149
Score: 0.973
Data Source: STRINGDB
FZD9
Tbio
Family: GPCR
Novelty: 0.01414546
Score: 0.973
Data Source: STRINGDB
FZD2
Tbio
Family: GPCR
Novelty: 0.00774893
Score: 0.973
Data Source: STRINGDB
FZD5
Tbio
Family: GPCR
Novelty: 0.01673829
Score: 0.971
Data Source: STRINGDB
Publication Statistics
PubMed Score  173.32

PubMed score by year
PubTator Score  117.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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