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Tbio
CEP41
Centrosomal protein of 41 kDa

Protein Summary
Description
Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium. This gene encodes a centrosomal and microtubule-binding protein which is predicted to have two coiled-coil domains and a rhodanese domain. In human retinal pigment epithelial cells the protein localized to centrioles and cilia. Mutations in this gene have been associated with Joubert Syndrome 15; an autosomal recessive ciliopathy and neurological disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223208
  • ENSP00000223208
  • ENSG00000106477
  • ENST00000343969
  • ENSP00000342738
  • ENST00000489512
  • ENSP00000417815
  • ENST00000541543
  • ENSP00000445888
  • ENST00000616628
  • ENSP00000479252

Symbol
  • TSGA14
  • JBTS15
  • TSGA14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
histone modification site profile
0.93
transcription factor perturbation
0.91
kinase perturbation
0.71
small molecule perturbation
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.57   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.57   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1891414
83922
Rat
RGD:1562034
500069
Dog
centrosomal protein 41
VGNC:39128
482256
Horse
centrosomal protein 41
VGNC:16418
100071992
Cow
centrosomal protein 41
VGNC:27204
506914
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
centrosomal protein 41
Horse
centrosomal protein 41
Cow
centrosomal protein 41
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BYV8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Gene Ontology Terms (12)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (164)
1 – 10 of 164
TCTN1
Tbio
Novelty: 0.0657704
Score: 0.974
Data Source: STRINGDB
TMEM67
Tbio
Novelty: 0.02573267
Score: 0.968
Data Source: STRINGDB
CC2D2A
Tbio
Novelty: 0.03684487
Score: 0.968
Data Source: STRINGDB
AHI1
Tbio
Novelty: 0.01180688
Score: 0.965
Data Source: STRINGDB
TCTN2
Tbio
Novelty: 0.11617528
Score: 0.965
Data Source: STRINGDB
TCTN3
Tdark
Novelty: 0.24504659
Score: 0.965
Data Source: STRINGDB
TMEM216
Tbio
Novelty: 0.07870718
Score: 0.964
Data Source: STRINGDB
OFD1
Tbio
Novelty: 0.01032841
Score: 0.962
Data Source: STRINGDB
RPGRIP1L
Tbio
Novelty: 0.00819421
Score: 0.959
Data Source: STRINGDB
B9D1
Tbio
Novelty: 0.11567839
Score: 0.957
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.57

PubMed score by year
PubTator Score  4.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer