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Tbio
FIS1
Mitochondrial fission 1 protein

Protein Summary
Description
Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223136
  • ENSP00000223136
  • ENSG00000214253

Symbol
  • TTC11
  • TTC11
  • CGI-135
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
transcription factor binding site profile
0.8
disease perturbation
0.79
tissue
0.69
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 285.75   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 332   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 285.75   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 332   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
54.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
54.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fission, mitochondrial 1
740858
Macaque
fission, mitochondrial 1
714444
Mouse
MGI:1913687
66437
Rat
RGD:1306668
288584
Dog
fission, mitochondrial 1
VGNC:40884
479728
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fission, mitochondrial 1
Macaque
fission, mitochondrial 1
Mouse
Rat
Dog
fission, mitochondrial 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y3D6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Class I peroxisomal membrane protein import (R-HSA-9603798)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class I peroxisomal membrane protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Class I peroxisomal membrane protein import
Protein localization
Gene Ontology Terms (39)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (164)
1 – 10 of 164
RAB24
Tbio
Family: Enzyme
Novelty: 0.04382232
p_int: 0.999999936
p_ni: 6.4e-8
Data Source: BioPlex
TBC1D17
Tdark
Novelty: 0.64376132
p_int: 0.99999912
p_ni: 8.8e-7
Score: 0.911
Data Source: BioPlex,STRINGDB
BRF2
Tbio
Novelty: 0.39111125
p_int: 0.999958245
p_ni: 1.68e-7
p_wrong: 0.000041587
Data Source: BioPlex
RAB14
Tbio
Family: Enzyme
Novelty: 0.01876172
p_int: 0.999880037
p_ni: 0.000119963
Data Source: BioPlex
EVI5L
Tbio
Novelty: 0.70769557
p_int: 0.999840221
p_ni: 0.000158733
p_wrong: 0.000001046
Data Source: BioPlex
UHRF1BP1
Tbio
Novelty: 0.1588079
p_int: 0.998880287
p_ni: 0.001119712
p_wrong: 1e-9
Data Source: BioPlex
TBC1D15
Tbio
Novelty: 0.11296513
p_int: 0.998800784
p_ni: 0.001199216
Score: 0.971
Data Source: BioPlex,STRINGDB
RABGAP1
Tbio
Family: Enzyme
Novelty: 0.14270101
p_int: 0.998171301
p_ni: 0.001828699
Data Source: BioPlex
VPS13A
Tbio
Novelty: 0.00581335
p_int: 0.99769719
p_ni: 0.00230281
Data Source: BioPlex
QSOX1
Tbio
Family: Enzyme
Novelty: 0.02152583
p_int: 0.997459187
p_ni: 0.00253305
p_wrong: 0.000007763
Data Source: BioPlex
Publication Statistics
PubMed Score  285.75

PubMed score by year
PubTator Score  86.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer