You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
SERPINE1
Plasminogen activator inhibitor 1

Protein Summary
Description
Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin format ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223095
  • ENSP00000223095
  • ENSG00000106366

Symbol
  • PAI1
  • PLANH1
  • PAI
  • PAI1
  • PAI-1
  • PLANH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
0.99
gene perturbation
0.96
PubMedID
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6528.35   (req: < 5)
Gene RIFs: 963   (req: <= 3)
Antibodies: 1326   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6528.35   (req: >= 5)
Gene RIFs: 963   (req: > 3)
Antibodies: 1326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 69
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
13.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
13.7
Protein Data Bank (21)
1 – 5 of 21
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (112)
BMAL1:CLOCK,NPAS2 activates circadian gene expression (R-HSA-1368108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Circadian Clock
Reactome
Dissolution of Fibrin Clot
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Circadian Clock
Dissolution of Fibrin Clot
ECM proteoglycans
Extracellular matrix organization
Protein-Protein Interactions (318)
1 – 10 of 318
PLAT
Tclin
Family: Enzyme
Novelty: 0.00017503
Score: 0.999
Data Source: Reactome,STRINGDB
PLAU
Tchem
Family: Enzyme
Novelty: 0.0005322
Score: 0.999
Data Source: Reactome,STRINGDB
PLG
Tclin
Family: Enzyme
Novelty: 0.00004806
Score: 0.998
Data Source: STRINGDB
VTN
Tbio
Family: TF
Novelty: 0.00046861
Score: 0.998
Data Source: Reactome,STRINGDB
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00087642
Score: 0.99
Data Source: Reactome,STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.982
Data Source: STRINGDB
TGFB1
Tchem
Novelty: 0.0001299
Score: 0.979
Data Source: STRINGDB
ALB
Tchem
Novelty: 0.00000616
Score: 0.979
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.979
Data Source: STRINGDB
VWF
Tbio
Novelty: 0.00009007
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score  6528.35

PubMed score by year
PubTator Score  4911

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: