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Tclin
CYP3A5
Cytochrome P450 3A5

Protein Summary
Description
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222982
  • ENSP00000222982
  • ENSG00000106258
  • ENST00000439761
  • ENSP00000401269
  • ENST00000646887
  • ENSP00000496704

Symbol
  • CP35
  • PCN3
  • CYPIIIA5
  • P450PCN3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
biological term
0.97
chemical
0.97
transcription factor perturbation
0.84
cell type or tissue
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1041.28   (req: < 5)
Gene RIFs: 367   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1041.28   (req: >= 5)
Gene RIFs: 367   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
kidney transplant
1
2
3
95.7
tacrolimus measurement
1
2
3
95.7
1
1
1
75.9
urinary metabolite measurement
1
1
1
75.9
neutrophil count
1
1
1
39.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
kidney transplant
3
95.7
tacrolimus measurement
3
95.7
1
75.9
urinary metabolite measurement
1
75.9
neutrophil count
1
39.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 3 subfamily A member 5
VGNC:7372
737374
Mouse
MGI:88610
13113
Rat
RGD:708392
171352
Dog
cytochrome P450 3A26
415127
Horse
cytochrome p450 3A95
100067109
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 3 subfamily A member 5
Mouse
Rat
Dog
cytochrome P450 3A26
Horse
cytochrome p450 3A95
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20815-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (85)
Aflatoxin activation and detoxification (R-HSA-5423646)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aflatoxin activation and detoxification
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Aflatoxin activation and detoxification
Biological oxidations
Cytochrome P450 - arranged by substrate type
Metabolism
Phase I - Functionalization of compounds
Gene Ontology Terms (16)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (122)
1 – 10 of 122
CYP3A7
Tclin
Family: Enzyme
Novelty: 0.00736888
p_int: 0.999999926
p_wrong: 7.5e-8
Score: 0.969
Data Source: BioPlex,STRINGDB
IGHG2
Tdark
p_int: 0.99256231
p_ni: 0.007435176
p_wrong: 0.000002514
Data Source: BioPlex
SERPINB4
Tbio
Novelty: 0.00522283
p_int: 0.989963871
p_ni: 0.010036129
Score: 0.222
Data Source: BioPlex,STRINGDB
IGHG1
Tdark
p_int: 0.955216659
p_ni: 0.044783341
p_wrong: 1e-9
Data Source: BioPlex
CYP2C9
Tchem
Novelty: 0.00041914
Score: 0.948
Data Source: STRINGDB
EPHX1
Tchem
Family: Enzyme
Novelty: 0.00220169
Score: 0.947
Data Source: STRINGDB
CYP1A1
Tchem
Novelty: 0.0002404
Score: 0.946
Data Source: STRINGDB
CYP2C19
Tchem
Novelty: 0.000394
Score: 0.946
Data Source: STRINGDB
CYP1A2
Tchem
Novelty: 0.00034756
Score: 0.945
Data Source: STRINGDB
CYP2B6
Tchem
Novelty: 0.00018351
Score: 0.944
Data Source: STRINGDB
Publication Statistics
PubMed Score  1041.28

PubMed score by year
PubTator Score  914.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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