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Tbio
DLX5
Homeobox protein DLX-5

Protein Summary
Description
Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chrom ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222598
  • ENSP00000222598
  • ENSG00000105880
  • ENST00000486603
  • ENSP00000475008
  • ENST00000648378
  • ENSP00000498116

Symbol
  • SHFM1D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.89
gene perturbation
0.88
protein domain
0.85
molecular function
0.84
PubMedID
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.68   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 476   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.68   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 476   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
88.1
bone density
1
2
2
24.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
88.1
bone density
2
24.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
distal-less homeobox 5
VGNC:4331
463554
Mouse
MGI:101926
13395
Rat
RGD:2506
25431
Dog
distal-less homeobox 5
VGNC:39992
482313
Horse
distal-less homeobox 5
VGNC:17222
100052263
Species
Name
OMA
EggNOG
Inparanoid
Chimp
distal-less homeobox 5
Mouse
Rat
Dog
distal-less homeobox 5
Horse
distal-less homeobox 5
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (36)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of RUNX2 expression and activity
Reactome
Transcriptional regulation by RUNX2
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of RUNX2 expression and activity
Transcriptional regulation by RUNX2
Gene Ontology Terms (27)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (110)
1 – 10 of 110
BMP2
Tbio
Novelty: 0.00016974
Score: 0.978
Data Source: STRINGDB
MSX2
Tbio
Family: TF
Novelty: 0.00273602
Score: 0.951
Data Source: STRINGDB
DLX6
Tbio
Family: TF
Novelty: 0.01455012
Score: 0.93
Data Source: STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.0003383
Score: 0.924
Data Source: STRINGDB
NKX3-2
Tbio
Family: TF
Novelty: 0.01804711
Score: 0.922
Data Source: STRINGDB
CBFB
Tchem
Family: TF
Novelty: 0.04825679
Score: 0.918
Data Source: STRINGDB
HIVEP3
Tbio
Family: TF
Novelty: 0.02321588
Score: 0.918
Data Source: STRINGDB
STUB1
Tbio
Family: Enzyme
Novelty: 0.00055102
Score: 0.905
Data Source: STRINGDB
WWP1
Tbio
Family: Enzyme
Novelty: 0.01407874
Score: 0.9
Data Source: STRINGDB
RUNX2
Tbio
Family: TF
Novelty: 0.00028804
Score: 0.882
Data Source: STRINGDB
Publication Statistics
PubMed Score  236.68

PubMed score by year
PubTator Score  85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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