You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PON1
Serum paraoxonase/arylesterase 1

Protein Summary
Description
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222381
  • ENSP00000222381
  • ENSG00000005421

Symbol
  • PON
  • ESA
  • PON
  • MVCD5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
chemical
0.99
disease
0.9
trait
0.75
molecular function
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3392.5   (req: < 5)
Gene RIFs: 850   (req: <= 3)
Antibodies: 533   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3392.5   (req: >= 5)
Gene RIFs: 850   (req: > 3)
Antibodies: 533   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
stem Cell Factor measurement
1
1
1
18.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
stem Cell Factor measurement
1
18.7
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of 5-eicosatetraenoic acids
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Fatty acid metabolism
Metabolism
Metabolism of lipids
Synthesis of 5-eicosatetraenoic acids
Gene Ontology Terms (26)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (122)
1 – 10 of 122
NFYC
Tbio
Family: TF
Novelty: 0.00626931
p_int: 0.999976623
p_ni: 0.000023377
Score: 0.82
Data Source: BioPlex,STRINGDB
NDUFB6
Tclin
Family: Enzyme
Novelty: 0.075245
p_int: 0.998940099
p_ni: 0.00059768
p_wrong: 0.000462221
Score: 0.187
Data Source: BioPlex,STRINGDB
PON3
Tbio
Family: Enzyme
Novelty: 0.00708429
p_int: 0.99707541
p_ni: 2e-9
p_wrong: 0.002924588
Score: 0.939
Data Source: BioPlex,STRINGDB
SFXN5
Tdark
Novelty: 0.30379915
p_int: 0.974065425
p_ni: 0.025934562
p_wrong: 1.3e-8
Score: 0.169
Data Source: BioPlex,STRINGDB
RDH13
Tbio
Family: Enzyme
Novelty: 0.20184998
p_int: 0.971512324
p_ni: 0.028487676
Score: 0.189
Data Source: BioPlex,STRINGDB
MICU2
Tbio
Novelty: 0.04146208
p_int: 0.956094372
p_ni: 0.043905628
Score: 0.172
Data Source: BioPlex,STRINGDB
APOA1
Tbio
Novelty: 0.0001216
Score: 0.956
Data Source: STRINGDB
APOA2
Tbio
Novelty: 0.00117627
Score: 0.946
Data Source: STRINGDB
LCAT
Tbio
Family: Enzyme
Novelty: 0.00307544
Score: 0.935
Data Source: STRINGDB
LPA
Tbio
Family: Enzyme
Novelty: 0.00054858
Score: 0.93
Data Source: STRINGDB
Publication Statistics
PubMed Score  3392.50

PubMed score by year
PubTator Score  2314.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer