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Tbio
RASIP1
Ras-interacting protein 1

Protein Summary
Description
Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222145
  • ENSP00000222145
  • ENSG00000105538

Symbol
  • RAIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
tissue sample
0.78
gene perturbation
0.72
transcription factor
0.63
transcription factor binding site profile
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.66   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.66   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
2
4
93.5
alcohol consumption measurement
2
1
2
92.8
mean platelet volume
3
2
3
88.2
alcohol use disorder measurement
1
1
1
86.6
diet measurement
6
4
6
71.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
4
93.5
alcohol consumption measurement
2
92.8
mean platelet volume
3
88.2
alcohol use disorder measurement
1
86.6
diet measurement
6
71.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ras interacting protein 1
VGNC:12072
747578
Macaque
Ras interacting protein 1
718836
Mouse
MGI:1917153
69903
Rat
RGD:1305291
292912
Dog
Ras interacting protein 1
VGNC:45374
484397
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ras interacting protein 1
Macaque
Ras interacting protein 1
Mouse
Rat
Dog
Ras interacting protein 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q5U651-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (54)
1 – 10 of 54
PPP1R18
Tbio
Novelty: 0.18837599
p_int: 0.999998868
p_wrong: 0.000001132
Score: 0.524
Data Source: BioPlex,STRINGDB
ARHGAP29
Tbio
Family: Enzyme
Novelty: 0.05574918
Score: 0.905
Data Source: STRINGDB
RAP1B
Tbio
Family: Enzyme
Novelty: 0.00627538
Score: 0.888
Data Source: STRINGDB
RRAS2
Tbio
Family: Enzyme
Novelty: 0.01870067
Score: 0.832
Data Source: STRINGDB
RAP2A
Tbio
Family: Enzyme
Novelty: 0.00541101
Score: 0.734
Data Source: STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00375413
Score: 0.722
Data Source: STRINGDB
RRAS
Tbio
Family: Enzyme
Novelty: 0.00786502
Score: 0.72
Data Source: STRINGDB
TMEM160
Tdark
Novelty: 0.73483266
Score: 0.686
Data Source: STRINGDB
HM13
Tbio
Family: Enzyme
Novelty: 0.0051333
Score: 0.664
Data Source: STRINGDB
NOP53
Tbio
Novelty: 0.00353077
Score: 0.653
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.66

PubMed score by year
PubTator Score  142.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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