You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
EPOR
Erythropoietin receptor

Protein Summary
Description
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling. This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222139
  • ENSP00000222139
  • ENSG00000187266
  • ENST00000592375
  • ENSP00000467809

Symbol
  • EPO-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.92
hub protein
0.9
kinase perturbation
0.84
virus perturbation
0.76
gene perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 827.49   (req: < 5)
Gene RIFs: 144   (req: <= 3)
Antibodies: 822   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 827.49   (req: >= 5)
Gene RIFs: 144   (req: > 3)
Antibodies: 822   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
erythropoetin measurement
1
1
0
1.5
73.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
erythropoetin measurement
0
1.5
73.8
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (168)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (R-HSA-9027276)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Reactome
Erythropoietin activates Phospholipase C gamma (PLCG)
Reactome
Erythropoietin activates RAS
Reactome
Erythropoietin activates STAT5
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Erythropoietin activates RAS
Erythropoietin activates STAT5
Signal Transduction
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (170)
1 – 10 of 170
EPO
Tbio
Novelty: 0.00013701
p_int: 0.966331816
p_ni: 7.7e-8
p_wrong: 0.033668107
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.995
Data Source: Reactome,STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.989
Data Source: Reactome,STRINGDB
STAT5B
Tchem
Family: TF
Novelty: 0.00074178
Score: 0.982
Data Source: Reactome,STRINGDB
LYN
Tclin
Family: Kinase
Novelty: 0.00097393
Score: 0.976
Data Source: Reactome,STRINGDB
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00110273
Score: 0.971
Data Source: Reactome,STRINGDB
KIT
Tclin
Family: Kinase
Novelty: 0.00011237
Score: 0.97
Data Source: STRINGDB
KITLG
Tbio
Novelty: 0.00036337
Score: 0.97
Data Source: STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.965
Data Source: Reactome,STRINGDB
SOCS3
Tbio
Novelty: 0.00106095
Score: 0.963
Data Source: STRINGDB
Publication Statistics
PubMed Score  827.49

PubMed score by year
PubTator Score  410.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: