You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CD79A
B-cell antigen receptor complex-associated protein alpha chain

Protein Summary
Description
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells. The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-ce ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221972
  • ENSP00000221972
  • ENSG00000105369
  • ENST00000444740
  • ENSP00000400605

Symbol
  • IGA
  • MB1
  • IGA
  • MB-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
PubMedID
0.62
cellular component
0.6
kinase
0.6
tissue
0.56


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 779.15   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 2045   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 779.15   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 2045   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD79a molecule
VGNC:3643
740560
Mouse
MGI:101774
12518
Rat
RGD:6484896
100913063
Dog
CD79a molecule
VGNC:38973
484483
Horse
CD79a molecule
VGNC:16279
100052219
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD79a molecule
Mouse
Rat
Dog
CD79a molecule
Horse
CD79a molecule
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
CD22 mediated BCR regulation
Reactome
Immune System
Reactome
Signaling by the B Cell Receptor (BCR)
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
CD22 mediated BCR regulation
Immune System
Signaling by the B Cell Receptor (BCR)
Protein-Protein Interactions (223)
1 – 10 of 223
ATP23
Tbio
Family: Enzyme
Novelty: 0.09823059
p_int: 0.999658571
p_ni: 0.000242091
p_wrong: 0.000099338
Data Source: BioPlex
NME4
Tbio
Family: Kinase
Novelty: 0.03735196
p_int: 0.991460706
p_ni: 0.008539291
p_wrong: 3e-9
Data Source: BioPlex
TTC28
Tdark
Novelty: 0.16651519
p_int: 0.988899414
p_ni: 0.011098958
p_wrong: 0.000001628
Data Source: BioPlex
SLC10A7
Tbio
Family: Transporter
Novelty: 0.15556211
p_int: 0.984884301
p_ni: 0.014898479
p_wrong: 0.00021722
Data Source: BioPlex
MTG2
Tbio
Family: Enzyme
Novelty: 0.06104792
p_int: 0.983760235
p_ni: 0.016231084
p_wrong: 0.000008681
Data Source: BioPlex
CDYL
Tchem
Family: Epigenetic
Novelty: 0.03367841
p_int: 0.97801177
p_ni: 0.021988229
p_wrong: 1e-9
Data Source: BioPlex
METTL15
Tdark
Family: Enzyme
Novelty: 0.4575663
p_int: 0.976894143
p_ni: 0.023105816
p_wrong: 4.1e-8
Data Source: BioPlex
HARS2
Tbio
Family: Enzyme
Novelty: 0.00230399
p_int: 0.97114092
p_ni: 0.028859079
p_wrong: 1e-9
Data Source: BioPlex
TYK2
Tclin
Family: Kinase
Novelty: 0.00237955
p_int: 0.969054813
p_ni: 0.030928532
p_wrong: 0.000016655
Score: 0.187
Data Source: BioPlex,STRINGDB
MICU1
Tbio
Novelty: 0.00984731
p_int: 0.964775136
p_ni: 0.035224863
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  779.15

PubMed score by year
PubTator Score  1373.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer