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Tbio
AMH
Muellerian-inhibiting factor

Protein Summary
Description
This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this g ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221496
  • ENSP00000221496
  • ENSG00000104899

Symbol
  • MIF
  • MIF
  • MIS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.97
protein domain
0.73
tissue sample
0.6
tissue
0.56
disease
0.53


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4814.5   (req: < 5)
Gene RIFs: 288   (req: <= 3)
Antibodies: 436   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4814.5   (req: >= 5)
Gene RIFs: 288   (req: > 3)
Antibodies: 436   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
anti-Mullerian hormone
VGNC:2589
100608039
Mouse
MGI:88006
11705
Rat
RGD:2108
25378
Cow
anti-Mullerian hormone
VGNC:25864
280718
Opossum
anti-Mullerian hormone
100019515
Species
Name
OMA
EggNOG
Inparanoid
Chimp
anti-Mullerian hormone
Mouse
Rat
Cow
anti-Mullerian hormone
Opossum
anti-Mullerian hormone
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P03971-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by BMP
Reactome
Signaling by TGF-beta family members
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by BMP
Signaling by TGF-beta family members
Protein-Protein Interactions (136)
1 – 10 of 136
AMHR2
Tbio
Family: Kinase
Novelty: 0.00479939
Score: 0.993
Data Source: Reactome,STRINGDB
ACVR1
Tchem
Family: Kinase
Novelty: 0.00284646
Score: 0.958
Data Source: STRINGDB
SMAD5
Tbio
Family: TF
Novelty: 0.00405952
Score: 0.943
Data Source: STRINGDB
SMAD9
Tbio
Family: TF
Novelty: 0.00285887
Score: 0.942
Data Source: STRINGDB
FOXL2
Tbio
Family: TF
Novelty: 0.00224046
Score: 0.931
Data Source: STRINGDB
SMAD1
Tbio
Family: TF
Novelty: 0.02348173
Score: 0.922
Data Source: STRINGDB
SOX9
Tbio
Family: TF
Novelty: 0.00047439
Score: 0.911
Data Source: STRINGDB
FKBP1A
Tclin
Family: Enzyme
Novelty: 0.00116174
Score: 0.906
Data Source: STRINGDB
DMRT1
Tbio
Family: TF
Novelty: 0.00403133
Score: 0.897
Data Source: STRINGDB
GNRH1
Tbio
Novelty: 0.00020807
Score: 0.873
Data Source: STRINGDB
Publication Statistics
PubMed Score  4814.50

PubMed score by year
PubTator Score  2443.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer