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Tbio
EXOSC5
Exosome complex component RRP46

Protein Summary
Description
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221233
  • ENSP00000221233
  • ENSG00000077348

Symbol
  • CML28
  • RRP46
  • p12B
  • RRP46
  • RRP41B
  • Rrp46p
  • hRrp46p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
interacting protein
0.86
disease perturbation
0.79
transcription factor binding site profile
0.79
tissue sample
0.66


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.58   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.58   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exosome component 5
VGNC:2556
740020
Macaque
exosome component 5
705203
Mouse
MGI:107889
27998
Rat
RGD:1307861
308441
Dog
exosome component 5
VGNC:40526
611350
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exosome component 5
Macaque
exosome component 5
Mouse
Rat
Dog
exosome component 5
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NQT4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
KSRP (KHSRP) binds and destabilizes mRNA
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Deadenylation-dependent mRNA decay
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Gene Ontology Terms (21)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (265)
1 – 10 of 265
C1D
Tbio
Novelty: 0.00997109
p_int: 0.99975887
p_ni: 0.00024113
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOSC3
Tbio
Novelty: 0.03072164
p_int: 0.999147326
p_ni: 0.000852674
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOSC7
Tbio
Family: Enzyme
Novelty: 0.07422851
p_int: 0.998970696
p_ni: 0.001029304
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOSC1
Tbio
Novelty: 0.01386842
p_int: 0.99607636
p_ni: 0.00392364
Score: 0.999
Data Source: BioPlex,STRINGDB
MPHOSPH6
Tbio
Family: Enzyme
Novelty: 0.24387167
p_int: 0.991450948
p_ni: 0.008549052
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOSC8
Tbio
Family: Enzyme
Novelty: 0.02013403
p_int: 0.976054774
p_ni: 0.023945226
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOSC10
Tbio
Novelty: 0.00335571
Score: 0.999
Data Source: STRINGDB
EXOSC6
Tbio
Family: Enzyme
Novelty: 0.06031176
Score: 0.999
Data Source: STRINGDB
EXOSC2
Tbio
Novelty: 0.08163283
Score: 0.999
Data Source: STRINGDB
EXOSC4
Tbio
Family: Enzyme
Novelty: 0.00798796
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  26.58

PubMed score by year
PubTator Score  5.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer