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Tbio
AQP9
Aquaporin-9

Protein Summary
Description
Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol. The aquaporins are a family of water-selective membrane channels. This gene encodes a member of a subset of aquaporins called the aquaglyceroporins. This protein allows passage of a broad range of noncharged solutes and also stimulates urea transport and osmotic water permeability. This protein may also facilitate the uptake of glycerol in hepatic tissue . The encoded protein may also play a role in specialized leukocyte functions such as immunological response and bactericidal activity. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219919
  • ENSP00000219919
  • ENSG00000103569
  • ENST00000536493
  • ENSP00000441390

Symbol
  • SSC1
  • SSC1
  • AQP-9
  • T17287
  • HsT17287
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
virus perturbation
0.88
ligand (protein) perturbation
0.83
PubMedID
0.83
hub protein
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.06   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.06   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glycine measurement
1
1
1
39
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glycine measurement
1
39
Pathways (7)
Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
Passive transport by Aquaporins
Reactome
Transport of glycerol from adipocytes to the liver by Aquaporins
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
Passive transport by Aquaporins
Transport of glycerol from adipocytes to the liver by Aquaporins
Transport of small molecules
Gene Ontology Terms (30)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (64)
1 – 10 of 64
AQP12A
Tbio
Novelty: 0.04258853
Score: 0.829
Data Source: STRINGDB
AQP11
Tbio
Novelty: 0.0229197
Score: 0.829
Data Source: STRINGDB
MNDA
Tbio
Novelty: 0.01991479
Score: 0.818
Data Source: STRINGDB
FPR1
Tchem
Family: GPCR
Novelty: 0.00256884
Score: 0.718
Data Source: STRINGDB
GK
Tbio
Family: Kinase
Novelty: 0.00617547
Score: 0.68
Data Source: STRINGDB
NCF2
Tbio
Novelty: 0.00274685
Score: 0.665
Data Source: STRINGDB
CFTR
Tclin
Family: IC
Novelty: 0.00012639
Score: 0.643
Data Source: STRINGDB
FCGR3A
Tbio
Novelty: 0.0004214
Score: 0.601
Data Source: STRINGDB
S100A9
Tbio
Novelty: 0.00185141
Score: 0.601
Data Source: STRINGDB
S100A12
Tbio
Novelty: 0.0027286
Score: 0.584
Data Source: STRINGDB
Publication Statistics
PubMed Score  203.06

PubMed score by year
PubTator Score  144.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer