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Tbio
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Protein Summary
Description
Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219789
  • ENSP00000219789
  • ENSG00000103502
  • ENST00000566113
  • ENSP00000457340
  • ENST00000569956
  • ENSP00000457339
  • ENST00000570016
  • ENSP00000454453

Symbol
  • PIS
  • PIS1
  • PIS
  • PIS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.99
kinase perturbation
0.95
metabolite
0.83
cellular component
0.82


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.36   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.36   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
VGNC:5722
454028
Macaque
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
707141
Mouse
MGI:105491
52858
Rat
RGD:620576
192260
Dog
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
VGNC:54010
489940
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Macaque
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Mouse
Rat
Dog
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14735-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PI
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PI
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (169)
1 – 10 of 169
SMAP2
Tbio
Novelty: 0.70006863
p_int: 0.997010581
p_ni: 0.00287075
p_wrong: 0.000118669
Score: 0.216
Data Source: BioPlex,STRINGDB
YTHDF1
Tbio
Novelty: 0.02063275
p_int: 0.989615771
p_ni: 0.010384229
Data Source: BioPlex
DSCC1
Tbio
Novelty: 0.04747149
p_int: 0.958300611
p_ni: 0.041699389
Score: 0.188
Data Source: BioPlex,STRINGDB
TTC5
Tbio
Novelty: 0.12127698
p_int: 0.906983202
p_ni: 0.093016797
Score: 0.189
Data Source: BioPlex,STRINGDB
UQCC1
Tbio
Family: Enzyme
Novelty: 0.03937066
p_int: 0.830173555
p_ni: 0.169820002
p_wrong: 0.000006443
Score: 0.189
Data Source: BioPlex,STRINGDB
CDS1
Tbio
Family: Enzyme
Novelty: 0.08094799
Score: 0.983
Data Source: STRINGDB
CDS2
Tbio
Family: Enzyme
Novelty: 0.13210626
Score: 0.973
Data Source: STRINGDB
SACM1L
Tbio
Family: Enzyme
Novelty: 0.00499867
Score: 0.968
Data Source: STRINGDB
PI4KB
Tchem
Family: Kinase
Novelty: 0.00856875
Score: 0.957
Data Source: STRINGDB
PI4KA
Tchem
Family: Kinase
Novelty: 0.01701469
Score: 0.955
Data Source: STRINGDB
Publication Statistics
PubMed Score  178.36

PubMed score by year
PubTator Score  43.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer