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Tbio
CRYM
Ketimine reductase mu-crystallin

Protein Classes
Protein Summary
Description
Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors. Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-sy ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219599
  • ENSP00000219599
  • ENSG00000103316
  • ENST00000543948
  • ENSP00000440227
  • ENST00000639592
  • ENSP00000490961
  • ENSG00000283922
  • ENST00000640547
  • ENSP00000492104

Symbol
  • THBP
  • THBP
  • DFNA40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
molecular function
0.84
PubMedID
0.8
tissue sample
0.69
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.89   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 289   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.89   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Lysine catabolism (R-HSA-71064)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Lysine catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Lysine catabolism
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (18)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (68)
1 – 10 of 68
RNF126
Tbio
Family: Enzyme
Novelty: 0.11501597
p_int: 0.995713107
p_ni: 0.004286893
Score: 0.403
Data Source: BioPlex,STRINGDB
PIPOX
Tbio
Family: Enzyme
Novelty: 0.00144303
Score: 0.938
Data Source: STRINGDB
L3HYPDH
Tdark
Family: Enzyme
Novelty: 0.33333333
Score: 0.812
Data Source: STRINGDB
AASDH
Tdark
Family: Enzyme
Novelty: 0.28397566
Score: 0.775
Data Source: STRINGDB
CRYZL1
Tbio
Family: Enzyme
Novelty: 0.03945638
Score: 0.738
Data Source: STRINGDB
DAO
Tchem
Family: Enzyme
Novelty: 0.00368338
Score: 0.674
Data Source: STRINGDB
NTNG2
Tbio
Novelty: 0.04650385
Score: 0.672
Data Source: STRINGDB
SLC17A8
Tbio
Family: Transporter
Novelty: 0.00915373
Score: 0.671
Data Source: STRINGDB
TTR
Tclin
Novelty: 0.00009876
Score: 0.662
Data Source: STRINGDB
CBLN2
Tbio
Novelty: 0.12632989
Score: 0.661
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.89

PubMed score by year
PubTator Score  21.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer