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Tbio
TBL1X
F-box-like/WD repeat-containing protein TBL1X

Protein Summary
Description
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219). Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272). The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encode ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217964
  • ENSP00000217964
  • ENSG00000101849
  • ENST00000380961
  • ENSP00000370348
  • ENST00000407597
  • ENSP00000385988
  • ENST00000424279
  • ENSP00000394097
  • ENST00000645353
  • ENSP00000496215
  • ENST00000645686
  • ENSP00000493782
  • ENST00000646640
  • ENSP00000495556

Symbol
  • TBL1
  • EBI
  • TBL1
  • SMAP55
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
transcription factor binding site profile
0.95
protein domain
0.92
biological process
0.85
transcription factor
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3020.73   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3020.73   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
86.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
86.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
transducin beta like 1 X-linked
106995151
Mouse
MGI:1336172
21372
Rat
RGD:1563868
302711
Dog
transducin beta like 1 X-linked
611017
Horse
transducin beta like 1 X-linked
100054115
Species
Name
OMA
EggNOG
Inparanoid
Macaque
transducin beta like 1 X-linked
Mouse
Rat
Dog
transducin beta like 1 X-linked
Horse
transducin beta like 1 X-linked
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (43)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 38
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Circadian Clock
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Chromatin modifying enzymes
Chromatin organization
Circadian Clock
Gene Ontology Terms (24)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (205)
1 – 10 of 205
TBL1Y
Tbio
p_int: 0.999999991
p_ni: 9e-9
Data Source: BioPlex
GPS2
Tbio
Novelty: 0.00986158
p_int: 0.999999272
p_ni: 7.28e-7
Score: 0.985
Data Source: BioPlex,Reactome,STRINGDB
DGKG
Tbio
Family: Enzyme
Novelty: 0.03666646
p_int: 0.999807722
p_ni: 0.000192278
Data Source: BioPlex
CDK2AP1
Tbio
Family: Enzyme
Novelty: 0.01584718
p_int: 0.999045479
p_ni: 0.000954214
p_wrong: 3.07e-7
Data Source: BioPlex
CCL26
Tbio
Novelty: 0.00556498
p_int: 0.997940513
p_ni: 0.002056179
p_wrong: 0.000003308
Data Source: BioPlex
TSC22D4
Tbio
Family: TF
Novelty: 0.25451456
p_int: 0.975220339
p_ni: 0.024779658
p_wrong: 3e-9
Score: 0.257
Data Source: BioPlex,STRINGDB
MKX
Tbio
Novelty: 0.02160101
p_int: 0.970813913
p_ni: 0.029186085
p_wrong: 2e-9
Score: 0.342
Data Source: BioPlex,STRINGDB
C6orf141
Tdark
Novelty: 1.46022784
p_int: 0.969173114
p_ni: 0.03082688
p_wrong: 6e-9
Data Source: BioPlex
IL17RA
Tclin
Novelty: 0.00416706
p_int: 0.968353169
p_ni: 0.031586282
p_wrong: 0.000060548
Data Source: BioPlex
SERPINB2
Tbio
Novelty: 0.00204345
p_int: 0.94221786
p_ni: 0.057489441
p_wrong: 0.000292699
Data Source: BioPlex
Publication Statistics
PubMed Score  3020.73

PubMed score by year
PubTator Score  195.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer