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Tbio
RNF125
E3 ubiquitin-protein ligase RNF125

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:26027934, PubMed:26471729, PubMed:25591766, PubMed:27411375). Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation (PubMed:17460044, PubMed:26471729). Mediates ubiquitination and subsequent degradation of p53/TP53 (PubMed:25591766). Mediates ubiquitination and subsequent degradation of JAK1 (PubMed:26027934). Acts as a positive regulator of T-cell activation (PubMed:15843525). This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intrac ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217740
  • ENSP00000217740
  • ENSG00000101695

Symbol
  • TNORS
  • TRAC1
  • TRAC-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.79
transcription factor binding site profile
0.79
microRNA
0.75
cell type or tissue
0.74
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.8   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.8   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (100)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Negative regulators of DDX58/IFIH1 signaling
Name
Explore in Pharos
Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Immune System
Innate Immune System
Negative regulators of DDX58/IFIH1 signaling
Protein-Protein Interactions (54)
1 – 10 of 54
DDX58
Tbio
Family: Enzyme
Novelty: 0.00080099
Score: 0.974
Data Source: STRINGDB
IFIH1
Tbio
Family: Enzyme
Novelty: 0.00111499
Score: 0.971
Data Source: STRINGDB
UBE2D1
Tbio
Novelty: 0.00865867
Score: 0.964
Data Source: STRINGDB
UBE2L6
Tbio
Novelty: 0.03471633
Score: 0.958
Data Source: STRINGDB
UBE2D3
Tbio
Novelty: 0.01908446
Score: 0.951
Data Source: Reactome,STRINGDB
UBE2D2
Tbio
Novelty: 0.00603877
Score: 0.939
Data Source: STRINGDB
UBE2K
Tbio
Novelty: 0.00214955
Score: 0.918
Data Source: STRINGDB
NPLOC4
Tbio
Novelty: 0.01690434
Score: 0.909
Data Source: STRINGDB
UFD1
Tbio
Novelty: 0.01230296
Score: 0.904
Data Source: STRINGDB
SIKE1
Tbio
Novelty: 0.14549184
Score: 0.733
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.80

PubMed score by year
PubTator Score  11.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer