You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
OXT
Oxytocin-neurophysin 1

Protein Summary
Description
Neurophysin 1 specifically binds oxytocin. Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (PubMed:18174156). This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217386
  • ENSP00000217386
  • ENSG00000101405

Symbol
  • OT
  • OT
  • OT-NPI
  • OXT-NPI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
biological term
0.89
gene perturbation
0.72
disease
0.7
phenotype
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19903.66   (req: < 5)
Gene RIFs: 117   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19903.66   (req: >= 5)
Gene RIFs: 117   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (35)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (53)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (286)
1 – 10 of 286
SHC1
Tchem
Novelty: 0.00083615
p_int: 0.999997979
p_ni: 0.000002021
Score: 0.205
Data Source: BioPlex,STRINGDB
VHL
Tchem
Family: Enzyme
Novelty: 0.00285782
p_int: 0.999984441
p_ni: 0.000015559
Score: 0.619
Data Source: BioPlex,STRINGDB
CUL2
Tbio
Novelty: 0.00512916
p_int: 0.974512164
p_ni: 0.025487836
Score: 0.547
Data Source: BioPlex,STRINGDB
NIF3L1
Tbio
Novelty: 0.15581813
p_int: 0.917483112
p_ni: 0.082516825
p_wrong: 6.3e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
NFS1
Tbio
Family: Enzyme
Novelty: 0.01274706
p_int: 0.760056712
p_ni: 0.239943288
Score: 0.189
Data Source: BioPlex,STRINGDB
OXTR
Tclin
Family: GPCR
Novelty: 0.0007551
Score: 0.997
Data Source: Reactome,STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.986
Data Source: STRINGDB
TRH
Tbio
Novelty: 0.00052673
Score: 0.985
Data Source: STRINGDB
CCK
Tbio
Novelty: 0.00012268
Score: 0.983
Data Source: STRINGDB
AVP
Tbio
Novelty: 0.00016475
Score: 0.982
Data Source: STRINGDB
Publication Statistics
PubMed Score  19903.66

PubMed score by year
PubTator Score  2743.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: