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Tbio
SALL4
Sal-like protein 4

Protein Summary
Description
Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells. This gene encodes a zinc finger transcription factor thought to play a role in the development of abducens motor neurons. Defects in this gene are a cause of Duane-radial ray syndrome (DRRS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217086
  • ENSP00000217086
  • ENSG00000101115
  • ENST00000395997
  • ENSP00000379319

Symbol
  • ZNF797
  • DRRS
  • HSAL4
  • ZNF797
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.76
PubMedID
0.74
biological term
0.72
transcription factor binding site profile
0.69
tissue sample
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 323.81   (req: < 5)
Gene RIFs: 125   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 323.81   (req: >= 5)
Gene RIFs: 125   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
59.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
59.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
spalt like transcription factor 4
VGNC:10498
458342
Macaque
spalt like transcription factor 4
700309
Mouse
MGI:2139360
99377
Rat
RGD:1597672
686412
Dog
spalt like transcription factor 4
485931
Species
Name
OMA
EggNOG
Inparanoid
Chimp
spalt like transcription factor 4
Macaque
spalt like transcription factor 4
Mouse
Rat
Dog
spalt like transcription factor 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UJQ4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Intracellular signaling by second messengers
Reactome
PIP3 activates AKT signaling
Reactome
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Reactome
PTEN Regulation
Name
Explore in Pharos
Explore in Source
Developmental Biology
Intracellular signaling by second messengers
PIP3 activates AKT signaling
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
PTEN Regulation
Protein-Protein Interactions (161)
1 – 10 of 161
POU5F1
Tbio
Family: TF
Novelty: 0.00033974
Score: 0.994
Data Source: STRINGDB
NANOG
Tbio
Family: TF
Novelty: 0.00054893
Score: 0.994
Data Source: STRINGDB
SOX2
Tbio
Family: TF
Novelty: 0.00037089
Score: 0.981
Data Source: STRINGDB
LIN28A
Tbio
Family: TF
Novelty: 0.00199524
Score: 0.976
Data Source: STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.963
Data Source: STRINGDB
PHC1
Tbio
Novelty: 0.01530622
Score: 0.944
Data Source: STRINGDB
TBX5
Tbio
Family: TF
Novelty: 0.00272208
Score: 0.943
Data Source: STRINGDB
SUZ12
Tbio
Novelty: 0.00402353
Score: 0.941
Data Source: STRINGDB
EZH2
Tclin
Family: Epigenetic
Novelty: 0.00052816
Score: 0.935
Data Source: STRINGDB
RNF2
Tbio
Family: Enzyme
Novelty: 0.00859204
Score: 0.935
Data Source: STRINGDB
Publication Statistics
PubMed Score  323.81

PubMed score by year
PubTator Score  188.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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