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Tbio
UPK3A
Uroplakin-3a

Protein Summary
Description
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity). This gene encodes a member of the uroplakin family, a group of transmembrane proteins that form complexes on the apical surface of the bladder epithelium. Mutations in this gene may be associated with renal adysplasia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216211
  • ENSP00000216211
  • ENSG00000100373
  • ENST00000396082
  • ENSP00000379391

Symbol
  • UPK3
  • UP3A
  • UPK3
  • UPIII
  • UPIIIA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
cellular component
0.84
cell type or tissue
0.57
disease
0.5
transcription factor
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.25   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.25   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
4.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
4.9
Protein-Protein Interactions (32)
1 – 10 of 32
UPK1B
Tbio
Novelty: 0.0285906
Score: 0.951
Data Source: STRINGDB
UPK2
Tbio
Novelty: 0.01066132
Score: 0.921
Data Source: STRINGDB
UPK1A
Tbio
Novelty: 0.01748122
Score: 0.912
Data Source: STRINGDB
UPK3B
Tbio
Novelty: 0.12798085
Score: 0.781
Data Source: STRINGDB
KRT7
Tbio
Novelty: 0.00039796
Score: 0.675
Data Source: STRINGDB
SCGB3A2
Tbio
Novelty: 0.03658152
Score: 0.673
Data Source: STRINGDB
UPK3BL1
Tdark
Novelty: 5
Score: 0.67
Data Source: STRINGDB
UPK3BL2
Tdark
Novelty: 5
Score: 0.67
Data Source: STRINGDB
HMBS
Tbio
Family: Enzyme
Novelty: 0.00193847
Score: 0.662
Data Source: STRINGDB
TSPAN4
Tbio
Novelty: 0.03394894
Score: 0.652
Data Source: STRINGDB
Publication Statistics
PubMed Score  124.25

PubMed score by year
PubTator Score  62.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer