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Tbio
PVALB
Parvalbumin alpha

Protein Summary
Description
In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. The protein encoded by this gene is a high affinity calcium ion-binding protein that is structurally and functionally similar to calmodulin and troponin C. The encoded protein is thought to be involved in muscle relaxation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216200
  • ENSP00000216200
  • ENSG00000100362
  • ENST00000417718
  • ENSP00000400247
  • ENST00000620986
  • ENSP00000480913
  • ENSG00000274665
  • ENST00000625893
  • ENSP00000486144

Symbol
  • D22S749
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
disease perturbation
0.68
PubMedID
0.59
protein domain
0.58
cellular component
0.54


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3756.72   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 306   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3756.72   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
parvalbumin
697272
Mouse
MGI:97821
19293
Rat
RGD:3457
25269
Dog
parvalbumin
VGNC:45214
481278
Horse
parvalbumin
VGNC:22051
100069554
Species
Name
OMA
EggNOG
Inparanoid
Macaque
parvalbumin
Mouse
Rat
Dog
parvalbumin
Horse
parvalbumin
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Transcriptional Regulation by MECP2
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Transcriptional Regulation by MECP2
Protein-Protein Interactions (317)
1 – 10 of 317
SREBF1
Tbio
Family: TF
Novelty: 0.00055257
p_int: 0.998504372
p_ni: 0.00147592
p_wrong: 0.000019707
Score: 0.693
Data Source: BioPlex,STRINGDB
CALB1
Tbio
Novelty: 0.00037716
Score: 0.945
Data Source: STRINGDB
CALB2
Tbio
Novelty: 0.0004996
Score: 0.944
Data Source: STRINGDB
SST
Tbio
Novelty: 0.00005944
Score: 0.923
Data Source: STRINGDB
GAD1
Tbio
Family: Enzyme
Novelty: 0.00067443
Score: 0.901
Data Source: STRINGDB
CCK
Tbio
Novelty: 0.00012268
Score: 0.87
Data Source: STRINGDB
GAD2
Tbio
Family: Enzyme
Novelty: 0.00058427
Score: 0.865
Data Source: STRINGDB
NPY
Tbio
Novelty: 0.00012637
Score: 0.85
Data Source: STRINGDB
SDF4
Tbio
Novelty: 0.00105893
Score: 0.831
Data Source: STRINGDB
GRIN1
Tclin
Family: IC
Novelty: 0.0011807
Score: 0.815
Data Source: STRINGDB
Publication Statistics
PubMed Score  3756.72

PubMed score by year
PubTator Score  832.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer