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Tchem
ACR
Acrosin

Protein Summary
Description
Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216139
  • ENSP00000216139
  • ENSG00000100312
  • ENST00000636109
  • ENSP00000490828
  • ENSG00000283539

Symbol
  • ACRS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
gene perturbation
0.76
tissue sample
0.74
protein domain
0.73
biological process
0.71


Related Tools
GENEVA
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1467.5   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1467.5   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 24
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acrosin
VGNC:12799
458950
Macaque
acrosin
716579
Mouse
MGI:87884
11434
Rat
RGD:2024
24163
Dog
acrosin
VGNC:37526
606765
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acrosin
Macaque
acrosin
Mouse
Rat
Dog
acrosin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P10323-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Acrosome Reaction and Sperm:Oocyte Membrane Binding (R-HSA-1300645)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acrosome Reaction and Sperm:Oocyte Membrane Binding
Reactome
Fertilization
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Acrosome Reaction and Sperm:Oocyte Membrane Binding
Fertilization
Reproduction
Gene Ontology Terms (21)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (58)
1 – 10 of 58
ENTPD6
Tbio
Family: Enzyme
Novelty: 0.1019314
Score: 0.901
Data Source: STRINGDB
ENTPD5
Tbio
Family: Enzyme
Novelty: 0.01714402
Score: 0.8
Data Source: STRINGDB
ACRBP
Tbio
Novelty: 0.01158059
Score: 0.776
Data Source: STRINGDB
ZP2
Tbio
Novelty: 0.00310166
Score: 0.766
Data Source: STRINGDB
ENTPD3
Tbio
Family: Enzyme
Novelty: 0.01673548
Score: 0.757
Data Source: STRINGDB
ENTPD1
Tchem
Family: Enzyme
Novelty: 0.00139367
Score: 0.746
Data Source: STRINGDB
UNC50
Tbio
Novelty: 0.03652325
Score: 0.743
Data Source: STRINGDB
ZP3
Tbio
Novelty: 0.00140352
Score: 0.737
Data Source: STRINGDB
ITPA
Tbio
Family: Enzyme
Novelty: 0.00235169
Score: 0.711
Data Source: STRINGDB
SERPINA5
Tbio
Family: Enzyme
Novelty: 0.00152504
Score: 0.642
Data Source: STRINGDB
Publication Statistics
PubMed Score  1467.50

PubMed score by year
PubTator Score  1397.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer